Irina N. Zaitseva

Learn More
UNLABELLED Aristolochic acids are potent human carcinogens; the role of phase II metabolism in their bioactivation is unclear. Accordingly, we tested the ability of the partially reduced metabolites, N-hydroxyaristolactams (AL-NOHs), and their N-O-sulfonated and N-O-acetylated derivatives to react with DNA to form aristolactam-DNA adducts. AL-NOHs displayed(More)
Aristolochic acids (AA) are implicated in the development of chronic renal disease and upper urinary tract carcinoma in humans. Using in vitro approaches, we demonstrated that N-hydroxyaristolactams, metabolites derived from partial nitroreduction of AA, require sulfotransferase (SULT)-catalyzed conjugation with a sulfonyl group to form aristolactam-DNA(More)
Cersosimo, Eugenio, Irina N. Zaitseva, and Mohamed Ajmal. Effects of b-adrenergic blockade on hepatic and renal glucose production during hypoglycemia in conscious dogs. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E792–E797, 1998.—To investigate the role of b-adrenergic mechanisms in the counterregulatory response of the liver and kidney to hypoglycemia,(More)
  • 1