Irina Mladenova

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Since the advent of sensitive diagnostic blood tests for the detection of antibody to hepatitis C virus (HCV) in donors, there has been a large decline in the incidence of transfusion-related hepatitis. Globally, the infection has an estimated prevalence of 3%, with a prevailing 1% in Europe while varying geographically within a North-South gradient,(More)
After removal of histone H1 about 40% of DNA in chromatin acquires the sensitivity of naked DNA to DNAse I. Digestion of H1-depleted chromatin with DNAse I leads to a qualitative change in the digestion pattern, generating DNA fragments of approx. 200 b.p. and multiples, similar to those obtained with micrococcal nuclease. Both effects are reversed upon(More)
Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) are 2 common and widely disseminated agents throughout the world. H. pylori has been classified, by the International Agency for Research on Cancer conference, as a class I carcinogen, i.e. undoubted cause of gastric cancer. However, this infection does not explain all the epidemiological and(More)
Helicobacter pylori (H. pylori) infection spreads from person-to-person, however the precise mode of transmission (oral-oral, fecal-oral or gastro-gastric) is hitherto not known. Gaining understanding into the spread of the bacterium might be useful in identifying high-risk populations, especially in areas that have high rates of gastric malignancies or(More)
Gastric carcinogenesis involves a slow but continuous, stepwise evolution from superficial gastritis to glandular atrophy, metaplasia, dysplasia, and finally, to adenocarcinoma. In 1994, the International Agency for Research on Cancer defined Helicobacter pylori (H. pylori) as a group I carcinogen. Evidence supporting a causal association has been(More)
Sustainability rating systems such as LEED, BREEAM, and others, had a significant impact in the design and delivery of buildings and in the increased adoption and understanding of sustainability metrics, solutions and value proposition within governments, developers, and end-users. Sustainability rating systems facilitated the broad adoption of the term by(More)
A comparative study was carried out with two alkylating agents IMB-MM and IMB-97 which are di-(2-halogenoethyl) hydrazides of amino acid derivatives. They have been found to exert a high activity towards wide spectrum of experimental tumours. Both agents caused inhibition of incorporation of 3H-thymidine into DNA of melanoma B16, marrow, intestinal mucosa,(More)