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Antioxidants specifically addressed to mitochondria have been studied to determine if they can decelerate senescence of organisms. For this purpose, a project has been established with participation of several research groups from Russia and some other countries. This paper summarizes the first results of the project. A new type of compounds (SkQs)(More)
Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium.(More)
Ataxia-telangiectasia (AT) is a severe hereditary neurodegenerative disease developing in the presence of mutations in both alleles of the gene atm. This gene encodes the key protein of cell response to DNA damage—ATM protein kinase. During the appearance of double-strand DNA breaks, the ATM protein kinase is autophosphorylated and its active form appears(More)
An interdisciplinary study was carried out of the telomere length and polymorphism of genes of the renin-angiotensin (ACE) and serotonin (5HTR2A and 5HTTLPR) systems in a population of old and very old inhabitants of northwestern Russia, as well as on their relationships to data from clinical and geriatric anamneses and psychological characteristics. By the(More)
116 The influence of the geomagnetic field (GMF) on living systems is unquestionable [1]. The magnitude of the GMF induction varies greatly in different points of the earth surface (B = 35–70 µT), and in space at the height of orbital stations the magnetic background is reduced by more than three orders of magnitude [2, 3]. However, such a significant(More)
Ataxia telangiectasia (AT) is a severe hereditary autosomal recessive neurodegenerative disease associated with accelerated aging and caused by mutation in both alleles of the atm gene. This gene encodes a key protein of cell response to DNA damage—the ATM protein kinase. Normally, upon formation of DNA double strand breaks, ATM is autophosphorylated and(More)
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