Irina I. Tarasenko

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The third intracellular loop (ICL3) of G protein-coupled receptors has, as a rule, a key role in their interaction with heterotrimeric G proteins. We synthesized peptides corresponding to the C-terminal region of the ICL3 (C-ICL3) of 5-hydroxytryptamine receptors of the type 1B (5-HT1BR) and 6 (5-HT6R) and studied their influence on the functional activity(More)
We and other authors have shown that synthetic peptides corresponding to regions of the third cytoplasmic loop (CL-3) of receptors of the serpentine type are capable of activating G-protein signaling cascades and triggering them in the absence of a hormone. To create selective regulators of hormonal signaling systems on the basis of these peptides, the(More)
Proximal regions of the third intracellular loop (ICL-3) are responsible for the interaction with heterotrimeric G proteins in most of the serpentine type receptors. The peptides corresponding to these regions are able to activate G proteins in the absence of hormone and to alter the transduction of hormonal signal via the respective homologous receptor.(More)
Asymmetrical lysine dendrimers are promising as vectors for delivering gene expression constructs into mammalian cells. The condensing, protective, and transfection properties were studied for pentaspherical lysine dendrimer D5 and its analog D5C10, modified with capric acid residues at the outer sphere; in addition, the transfection activity was assayed(More)
94 A topical problem of modern biochemistry and molecular endocrinology is the search for highly selec tive regulators of hormonal signaling systems. Many hormones bind to several types of receptors that are coupled to different heterotrimeric GTP binding pro teins (G protein). This leads to a simultaneous activa tion of several signaling cascades,(More)
We attempted to find some compounds for the effective delivery of gene constructs into cells and obtained two trispherical dendrimers on the basis of lysine, (Lys)8-(α,ε-Lys)4-(α,ε-Lys)2-(α,ε-Lys)-Ala-NH2 (D1) and ((Lys)8-(α,ε-Lys)4-(α,ε-Lys)2-α,ε-Lys)-Ala-[Lys(Plm)]2-Ala-NH2 (D2), as well as the starburst polymeric derivatives of D1, (pVIm) 8 -D1 and(More)
We attempted to find some compounds for the effective delivery of gene constructs into cells and obtained two trispherical dendrimers on the basis of lysine, (Lys)8-(alpha, epsilon-Lys)4-(alpha, epsilon-Lys)2-(alpha, epsilon-Lys)-Ala-NH2 (D1) and (Lys)8-(alpha, epsilon-Lys)4-(alpha, epsilon-Lys)2-(alpha, epsilon-Lys)-Ala-[Lys(Plm)]2-Ala-NH2 (D2), as well as(More)
In animals of different phylogenetic levels, polycationic peptides are one of the most important regulators of the functional activities of hormonal signaling systems, including the adenylate cyclase signaling system (AC system). We compared the functional state of the AC system in the rat brain after treatment with three synthetic polycationic peptides(More)
from q/11-family G-proteins. In 2013, it was demonstrated that GPR146 receptor can function as a specific C-peptide receptor, as evidenced by the following facts [3]. The GPR146 gene is expressed in all cells that are sensitive to C-peptide. C-peptide co-localizes with GPR146 receptor and induces its internalization, while this effect is highly(More)
The aim of this work was to study the effect of multiple (during 12 months) immunization of rats with BSA-conjugated peptide 189–205 corresponding to the second extracellular loop of rat HT1BR on ACSS activity in the brain of immunized animals (group HT1BR) and its regulation by hormones.