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  • Irina G. Gazaryan, Inna P Krasinskaya, Bruce S. Kristal, Abraham M. Brown
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2007 (First Publication: 17 August 2007)
  • Recent observations point to the role played by Zn2+ as an inducer of neuronal death. Two Zn2+ targets have been identified that result in inhibition of mitochondrial respiration: the bc1 center and,Expand
  • Irina G. Gazaryan, Boris F. Krasnikov, G. A. Ashby, Roger N. F. Thorneley, Bruce S. Kristal, Abraham M. Brown
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 22 March 2002)
  • Submicromolar zinc inhibits α-ketoglutarate-dependent mitochondrial respiration. This was attributed to inhibition of the α-ketoglutarate dehydrogenase complex (Brown, A. M., Kristal, B. S., Effron,Expand
  • Manuj Ahuja, Navneet Ammal Kaidery, +13 authors Bobby Thomas
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2016 (First Publication: 8 June 2016)
  • A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of antioxidant,Expand
  • P. A. Savitsky, Irina G. Gazaryan, Vladimir I Tishkov, L Mark Lagrimini, Tautgirdas Ruzgas, Lo Gorton
  • Medicine, Chemistry
  • The Biochemical journal
  • 1999 (First Publication: 15 June 1999)
  • Indole-3-acetic acid (IAA) can be oxidized via two mechanisms: a conventional hydrogen-peroxide-dependent pathway, and one that is hydrogen-peroxide-independent and requires oxygen. It has been shownExpand
  • Natalya A Smirnova, Renée E. Haskew-Layton, +9 authors Irina G. Gazaryan
  • Medicine, Biology
  • Chemistry & biology
  • 2011 (First Publication: 24 June 2011)
  • The NF-E2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant defense and detoxification. To directly monitor stabilization of Nrf2, we fused its Neh2 domain, responsible forExpand
  • Irina G. Gazaryan, L Mark Lagrimini, G. A. Ashby, Roger N. F. Thorneley
  • Medicine, Chemistry
  • The Biochemical journal
  • 1996 (First Publication: 1 February 1996)
  • Indole-3-acetic acid (IAA) is a powerful plant growth regulator. The oxidative decarboxylation of IAA by plant peroxidases is thought to be a major degradation reaction involved in controlling the inExpand
  • Renée E. Haskew-Layton, Jimmy B Payappilly, +13 authors Rajiv R. Ratan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 20 September 2010)
  • Neurons rely on their metabolic coupling with astrocytes to combat oxidative stress. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) appears important forExpand