Irina G. Lilp

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Studies of behavior, neurophysiological reactions, neuromediator synthesis and brain structure of mice of the 101/HY strain (including those of the authors) are reviewed. This mouse strain is characterized by a chromosomal instability because of a recessive mutation mutator-1(mut-1) and the defective DNA excision repair. Experimental studies revealed a(More)
The data are presented on intermale aggression in mice which were selected for high scores of cognitive trait (the ability for extrapolation of movement direction) in comparison to the data of control mice performance. The changes in aggression level in the course of selection are presumably connected with anxiety level which also changed during selection(More)
effect in a concentration of 5 ~g per Petri dish in experiments on salmonellas [2]. It must also be borne in mind that, despite its fairly wide distribution in the environment, BP acts on man in relatively low concentrations. For example, the total dose of BP which can enter the human body during the lifetime of a person living in a zone polluted by waste(More)
Hungry mice from strain which is under selection for high scores of capacity for extrapolation the direction of stimulus movement (line EX) the hyponeophagia level (reaction to new food in novel environment) was significantly lower than in mice of control unselected population (CoEX). This signify their lower anxiety as well as higher neophilia (which in(More)
52 Genetic studies on the capacity of laboratory rodents for solving cognitive tasks are mainly based on the estimation of differences between the strains [8] and the changes in this ability after manipulations with the genome of laboratory mice [7]. In spite of much interest in studies on the role of the genotype in deter mination of cognitive capacities(More)
The selection for large and small relative brain weight (RBW) in mice, started in 1999, resulted in stable significant differences in the trait (16%). The selection was discontinued at F22, and both lines (Large Brain, LB and Small brain, SB) were maintained by random mating. In F25-F28 the significant differences in RBW were still present in spite of the(More)
Mice from the earlier developed recombinant inbred strains (RIS), which were derived by crossing 101/HY mice (carrying the mut-1 allele determining increased susceptibility to the mutagenic action of alkylating compounds) with C3H/Sn mice (lacking this trait), were tested for the presence of two neurological pathologies, audiogenic epilepsy and splitting of(More)
Mice with a knockout of the sodium–calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of the stimulus movement and the “puzzle-box” test for the capacity to find a hidden route to safe environment, which were(More)
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