Irina Favorskaya

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The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular retinoic acid-binding proteins (CRABP1 and CRABP2) are important modulators of RA activity. Up to date, the role of these proteins in cancer progression remains poorly investigated. Here, we studied for the first time the simultaneous messenger RNA(More)
Retinoids are signaling molecules that control a wide variety of cellular processes and possess antitumor activity. This work presents a comprehensive description of changes in the expression of 23 genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer tumors compared to adjacent normal tissues obtained using RT-PCR. Even at(More)
CRABP1 (cellular retinoic acid binding protein 1) belongs to the family of fatty acid binding proteins. Retinoic acid binding is the only known functional activity of this protein. The role of CRABP1 in human carcinogenesis remains poorly understood. Here, for the first time we demonstrated pro-metastatic and pro-tumorigenic activity of CRABP1 in(More)
147 Platinum derivatives are widely used to treat tumors of various origins, including lung cancer. The first drug of this group was cisplatin, or cis diam minedichloroplatinum (II). Later, carboplatin, oxali platin, and other drugs were developed [1]. At present, despite the pronounced toxicity of cisplatin, it contin ues to be used in combination with a(More)
20 1 Chemotherapy is one of the most common method in modern oncology along with surgery and radiation therapy. In some cases (particularly for non small cells lung cancer and for inoperable tumors) chemotherapy becomes a single method of choice [1]. Activation of cell chemoprotective mechanisms as well as reduced expression or defects of molecular targets(More)
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