Irina Degtyareva

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BACKGROUND The prevalence of extensively drug-resistant (XDR) tuberculosis is increasing due to the expanded use of second-line drugs in people with multidrug-resistant (MDR) disease. We prospectively assessed resistance to second-line antituberculosis drugs in eight countries. METHODS From Jan 1, 2005, to Dec 31, 2008, we enrolled consecutive adults with(More)
BACKGROUND Resistance to second-line drugs develops during treatment of multidrug-resistant (MDR) tuberculosis, but the impact on treatment outcome has not been determined. METHODS Patients with MDR tuberculosis starting second-line drug treatment were enrolled in a prospective cohort study. Sputum cultures were analyzed at a central reference laboratory.(More)
In the NMR s pec t r a of compounds Ia and Ib, a na r row singlet was obse rved in the 11.47 ppm region (Ia) and the 11.49 ppm region (Ib) for a hydroxyl group (the 6-OH) which is involved in the fo rmat ion of an in t r a mo lecu l a r hydrogen bond with the CO f ragmen t of the neighboring e s t e r group (the 1-COOCH3) [1, 3, 4]. The m a r k e d high-f(More)
Until recently there was no generally recognized classification of synthetic antibacterial drugs, which was due to the limited understanding of the mechanism of their action at the molecular level. In an analysis of the modern data we used the division of the existing synthetic drugs into six chemlco-biological groups, taking the peculiarities of the(More)
Arylfuryllithium, formed by the interaction of arylfurans with butyl lithium, was treated in si~ with ethylene oxide to give the hydroxyethyl derivatives la-d. The structure of the compounds obtained was confirmed by the presence of absorption bands in the 3350-3500 and 1028-1055 cm -I regions of the IR, and of proton signals for the OH at 2.19 ppm (s),*(More)
Certain questions of the mechanism of the action of antimicrobial (sanguiritrin and lutenurin) and antiviral (alpizarin) drugs developed at the All-Union Scientific Research Institute of Medicinal Plants were studied in this work. The sources of production and spectrum of action of these drugs are cited in Table i [3, 4, 7]. In clinical testing these drugs(More)
T~is material is protected by copyright registered in the name o f Plenum Publishing Corporation. 227 West 1 7th Street. New York, IV. Y. 10011. No part o f this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, elec tronic, mechanical, photocopying, microfilming, recording or otherwise, wi thout(More)
A rational approach to the creation of antimicrobial preparations is based on the study of their influence on the specific peculiarities of the metabolism of the pathogen of the infectious process. Howeverp only in the last decades have the successes of molecular biology permitted the disclosure of the molecular mechanisms of the action of a number of(More)
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