Irina Bocharova

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Surfactants have the potential to overcome natural resistance of MTB to antibiotics which is mediated by barriers that impede the penetration of drugs to their targets. A major component of this barrier is trehalose dimycolate (TDM) which surrounds the bacteria with a thick lipid shield. In this study dodecyl maltoside (DDM) was evaluated for this purpose.(More)
centroid, 19, 25, 30 circular displacement, 102 code convolutional, 36, 58 Elias, 256 Gallager-vanVoorhis, 255 Golomb, 218, 254 Golomb–Rice, 188 Levenstein, 256 monotonic, 254 prefix-free, 239 terminated convolutional, 37 trellis, 38 unary, 254 zero-tail terminated convolutional, 37 codebook, 26, 27 adaptive, 154 adaptive gain, 155 stochastic, 156(More)
The advisability of processing copper-nickel ore dressing tailings of current production has been substantiated. The optimal parameters of metal leaching with sulphuric acid have been determined. In laboratory experiments the geotechnological extraction of non-ferrous metals from a leaching layer representing a tailing material of fraction +0.063 mm has(More)
The study deals with the evaluation of antimycobacterial activity of betulinol, a dry birch bark extract (BBE), on a model of infection caused by Mycobacterium tuberculosis (MBT). It has established the inhibitory action of betulinol on the in vitro and in vivo growth of MBT and its positive effect on reparative processes in the lung, liver, and spleen of(More)
DST was ascertained to have a high sensitivity in virtually all patients with tuberculosis and a positive reaction was first noted in the infected. With stabilization and regression, the response to DST was much less pronounced than that in clinical and primary infection (that to the Mantoux test being more evident). DST showed its use as a marker of active(More)
The authors studied the efficiency of use of bone marrow cells in the treatment of experimental tuberculosis. Bone marrow cell transplantation to H37Rv tuberculosis-infected H37Rv mice was shown to prolong the life span in the animals as compared to untreated animals. Examination of humoral immunity indicated that administration of allogenic bone marrow(More)
In inbred CBA and CBA/N mice immunological memory was induced by subcutaneous injection of Mycobacterium bovis (BCG). Experiments with adoptive transfer of spleen T cells and ionomycin-resistant T cells (memory cells) between CBA and CBA/N mice in various combinations showed that immunological memory was not formed in CBA/N mice, but can be induced by(More)
The impact of the in vivo administration of monoclonal antibodies against cytokines on the development of a pathological process in mice infected with Mycobacterium tuberculosis H37Rv-infected mice. The susceptibility to fatal experimental tuberculosis, the level of DTH to mycobacterial antigens, the production of specific antimycobacterial IgG and IgM,(More)
Mice of the genetically TB-susceptible strain I/St were infected with ∼100 CFU of Mycobacterium tuberculosis strain H37Rv, and after week 3 post-infection treated by inhalations of the NBD peptide selectively blocking NF-κB activation pathway. This therapy resulted in a pronounced attenuation of lung pathology and down-regulation of the expression of(More)