Irina A Tikhomirova

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Exposure of red blood cells (RBCs) to catecholamines (epinephrine, phenylephrine, an agonist of alpha1-adrenergic receptors, clonidine, an agonist of alpha2-adrenergic receptors and isoproterenol, an agonist of beta-adrenergic receptors) led to change in the RBC microrheological properties. When forskolin (10 microM), an AC stimulator was added to RBC(More)
There are evidences that red blood cell (RBC) deformation and aggregation change under their incubation with catecholamines and it is connected with activation of intracellular signaling pathways. The present study was designed to explore the adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism of RBCs together with their microrheological(More)
The exposure of red blood cells (RBC) to some hormones (epinephrine, insulin and glucagon) and agonists of α- and β-adrenergic receptors (phenylephrine, clonidine and isoproterenol) may modify RBC aggregation (RBCA). Prostaglandin E1 (PGE1) significantly decreased RBCA, and PGE2 had a similar but lesser effect. Adenylyl cyclase (AC) stimulator forskolin(More)
This study was designed to evaluate hemorheological changes in patients with cerebrovascular disease (CVD) and peripheral arterial disease (PAD) after 4 weeks of pentoxifylline therapy as well as to study red blood cell microrheological variables after the cell incubation with pentoxifylline and some phosphodiesterase (PDE) activity inhibitors. The patients(More)
The extent of aggregation, electrophoretic mobility, and zeta potential of human erythrocytes were measured in the presence of some hormones and prostaglandins. Catecholamines, adrenomimetics, and prostaglandins were found to significantly increase the extent of aggregation; the electrophysiological characteristics of the cells were affected in different(More)
The purpose of this study was to estimate drug effect on red blood cell (RBC) microrheological properties making for blood transport efficiency. It is well known that blood flow in microcirculation, tissue perfusion and oxygenation depend on red blood cell (RBC) microrheological properties, namely deformability (RBCD) and aggregability (RBCA). In turn the(More)
The aim of this study was to estimate effects of some chemotherapy drugs on the elasticity and deformability of the membrane of a red blood cell (RBC). It was found that incubation of red blood cells (RBCs) with cisplatin or epoetin alpha led to considerable (by 10–17%; p < 0.05) increase in the RBC deformability and that cisplatin could activate tyrosine(More)
Since the dehydration causes a loss of body water, we studied the rheological properties of blood in the course of water deprivation. Subjects used in this study were 64 white male rats divided into 4 groups: control (n=19) and 3 experimental groups which underwent water deprivation for 3 days (n=15), 6 days (n=15) and 10 days (n=15). The results obtained(More)
Hemorheological parameters were studied in patients with essential hypertension (men and women) and those with bronchial asthma. The rheological findings were established as a hemorheological profile. The latter is a set of macro- and microrheological parameters under various pathological conditions. The data show that blood viscosity was increased and(More)