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File systems hosting virtual machines typically contain many duplicated blocks of data resulting in wasted storage space and increased storage array cache footprint. Deduplication addresses these problems by storing a single instance of each unique data block and sharing it between all original sources of that data. While deduplica-tion is well understood(More)
Managing resources at large scale while providing performance isolation and efficient use of underlying hardware is a key challenge for any cloud management software. Most virtual machine (VM) resource management systems like VMware DRS clusters, Microsoft PRO and Eucalyptus, do not currently scale to the number of hosts and VMs supported by cloud service(More)
Virtualized datacenters strive to reduce costs through workload consolidation. Workloads exhibit a diverse set of IO behaviors and varying IO load that makes it difficult to estimate the IO performance on shared storage. As a result, system administrators often resort to gross overprovisioning or static partitioning of storage to meet application demands.(More)
Collection of detailed characteristics of disk I/O for workloads is the first step in tuning disk subsystem performance. This paper presents an efficient implementation of disk I/O workload characterization using online histograms in a virtual machine hypervisor—VMware ESX Server. This technique allows transparent and online collection of essential workload(More)
Rapid adoption of virtualization technologies has led to increased utilization of physical resources, which are mul-tiplexed among numerous workloads with varying demands and importance. Virtualization has also accelerated the deployment of shared storage systems, which offer many advantages in such environments. Effective resource management for shared(More)
Server virtualization is accelerating the already existing need for shared storage area network (SAN) infrastructure for the associated benefits of migration, flexible management and economies of sharing. Understanding the characteristics of a workload in terms of access locality, IO sizes, read write ratio etc. is crucial for effective placement and(More)
AIMS Two randomized, double-blind, placebo-controlled studies were performed to characterize the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of the investigational metastin analogue, TAK-683, in healthy men. METHODS We first investigated a single subcutaneous (s.c.) dose of TAK-683 (0.01-2.0 mg) in 60 subjects (TAK-683, n = 42;(More)
Bacterial survival depends on the ability to switch between sessile and motile lifestyles in response to changing environmental conditions. In many species, this switch is governed by (3'-5')-cyclic-diguanosine monophosphate (c-di-GMP), a signalling molecule, which is metabolized by proteins containing GGDEF and/or EAL domains. Salmonella Typhimurium(More)
©2003 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. Abstract The(More)
A prospective, cross-sectional, observational study in preterm and term infants was performed to compare multimodal measurements of body composition, namely, limb ultrasound, bone quantitative ultrasound, and dual X-ray absorptiometry (DXA). One hundred and two preterm and term infants appropriate for gestational age were enrolled from the newborn nursery(More)