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Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis
BackgroundIt is unclear to what extent pre-clinical studies in genetically homogeneous animal models of amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative disorder, can beExpand
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Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
(1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common andExpand
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A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry
Neurofilament proteins (Nf) are a biomarker of disease progression in amyotrophic lateral sclerosis (ALS). This study investigated whether there are major differences in expression from in vivoExpand
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Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis
The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), aExpand
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The proteome of neurofilament-containing protein aggregates in blood
Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. RecentExpand
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Nuevos mediadores implicados en la génesis de la aterosclerosis
La aterosclerosis es la enfermedad cardiovascular con mas morbimortalidad en paises desarrollados. Los nuevos habitos de vida, la falta de mecanismos eficaces en la deteccion temprana de laExpand
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Aproximación a la patogenia de la aterosclerosis. Análisis del secretoma de arterias humanas sanas y con distintos grados de afección
Aproximación a la patogenia de la aterosclerosis. Análisis del secretoma de arterias humanas sanas y con distintos grados de afección Fernando de la Cuesta*, María G. Barderas*, Enrique Calvo, IreneExpand