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Transglutaminase 2 (TG2) represents the most ubiquitous isoform belonging to the TG family, and has been implicated in the pathophysiology of basal ganglia disorders, such as Parkinson's disease and Huntington's disease. We show that ablation of TG2 in knockout mice causes a reduced activity of mitochondrial complex I associated with an increased activity(More)
In this study we provide the first in vivo evidences showing that, under physiological conditions, "tissue" transglutaminase (TG2) might acts as a protein disulphide isomerase (PDI) and through this activity contributes to the correct assembly of the respiratory chain complexes. Mice lacking TG2 exhibit mitochondrial energy production impairment, evidenced(More)
Apoptosis deregulation, since its discovery, has been shown to play an important role in the onset of numerous diseases including myocardial ischemia and reperfusion. Ischemic injury is thought to initiate apoptosis, but for substantial cell death to occur, reperfusion is necessary. Among many others the initial high-energy phosphate content of the heart(More)
We gratefully acknowledge a grant from the Medical Research Council from which the cost of this work was defrayed, the generosity of Dr M. N. Huffman of the Oklahoma Medical Research Foundation in sending us a specimen of authentic 16-epioestriol, the skill of Dr J. W. Minnis who carried out the microanalyses, the technical assistance of Miss Winifred(More)
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