Irene S. Alexander

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The use of large doses of methotrexate (MTX), greater than 3 g/m2, for the treatment of some malignant disorders requires careful monitoring of serum concentrations. A simple and sensitive method for the separation of MTX and 7-hydroxymethotrexate (7-OH-MTX) by reversed-phase high-performance liquid chromatography (HPLC) is described. The method involves(More)
* This material is based upon work supported by the National Science Foundation under Grant Nos. IIS-0102558 and IIS-0325035. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. Abstract We investigated human interaction(More)
Acute experimental synovitis was produced by intra-articular challenge of 3 baboons (Papio cynocephalus) sensitised with ovalbumin. Haemagglutination tests revealed high titres of circulating antiovalbumin antibody. Measurements were made of articular diameter, circumference, and temperature before the animals were killed on days 1, 5, and 20. The sterile(More)
Head retraction in infancy is a physical sign that is usually associated with central nervous system pathology. It is not generally recognised that head retraction can occur as a consequence of respiratory system abnormality, particularly in younger infants. Head retraction may be seen in any respiratory condition where decreased lung compliance or airway(More)
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