Irene Ol Ng

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Viral integration into the human genome upon infection is an important risk factor for various human malignancies. We developed viral integration site detection tool called Virus-Clip, which makes use of information extracted from soft-clipped sequencing reads to identify exact positions of human and virus breakpoints of integration events. With initial(More)
  • Irene Ol Ng
  • Journal of gastroenterology and hepatology
  • 1998
Mutations of the p53 gene are common in hepatocellular carcinoma (HCC) and have been found in 13-33% of HCC in Asia and 23% of HCC in Hong Kong. In addition, p53 overexpression has been found to be associated with poorer cellular differentiation and larger tumour size and may be a late event in hepatocarcinogenesis. The p53 gene is important in controlling(More)
Hepatocellular carcinoma (HCC) is especially prevalent in Hong Kong due to prevalent hepatitis B virus (HBV) infection. HBV-associated HCC has a male predominance, with a male-to-female ratio of about 4-5:1. This is in contrast to HCV-associated HCC that has a male-to-female ratio of 1.5-2:1. HBV is a partially double-stranded DNA virus containing four(More)
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