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An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder
- Aimilia Lydia Kalafateli, Daniel Vallöf, G. Colombo, I. Lorrai, P. Maccioni, E. Jerlhag
- 23 January 2019
Recent findings have identified salmon calcitonin (sCT), an amylin receptor agonist and analogue of endogenous amylin, as a potential regulator of alcohol-induced activation of the mesolimbic… Expand
Binge drinking and anxiety at the end of the nocturnal period in alcohol-preferring sP rats.
- G. Colombo, C. Lobina, I. Lorrai, Carla Acciaro, P. Maccioni, G. Gessa
- Psychology, Medicine
- 1 September 2017
Previous studies suggested that exposure of Sardinian alcohol-preferring (sP) rats to daily drinking sessions of 1 h, during the dark phase of the light/dark cycle, with multiple alcohol… Expand
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors
Rationale and objectivesCOR659 [methyl2-(4-chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate] is a new, positive allosteric modulator (PAM) of the GABAB receptor. This study evaluated… Expand
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a "history" of unpredictable, limited access to alcohol.
Recent research found that exposure of selectively bred, Sardinian alcohol-preferring (sP) rats to multiple alcohol concentrations (10%, 20%, and 30%, v/v), under the 4-bottle "alcohol vs. water"… Expand
R(+)-Baclofen, but Not S(−)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats
Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and mice. Recent data… Expand
Microinjection of baclofen and CGP7930 into the ventral tegmental area suppresses alcohol self-administration in alcohol-preferring rats
- P. Maccioni, I. Lorrai, A. Contini, K. Leite-Morris, G. Colombo
- Psychology, Medicine
- 1 October 2017
ABSTRACT Systemic administration of the orthosteric agonist, baclofen, and several positive allosteric modulators (PAMs) of the GABAB receptor has repeatedly been reported to decrease operant oral… Expand
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor
- P. Maccioni, I. Lorrai, M. A. Carai, A. Riva, G. Colombo
- Chemistry, Medicine
- Neuroscience Letters
- 16 May 2016
Recent studies demonstrated that treatment with saikosaponin A (SSA) - an active ingredient of the medicinal herb, Bupleurum falcatum L. - selectively suppressed, likely via a GABAB receptor-mediated… Expand
Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues.
A recent study found that COR659 (methyl 2-[(4-chlorophenyl)carboxamido]-4-ethyl-5-methylthiophene-3-carboxylate) reduced operant alcohol and chocolate self-administration in rats; COR659 also… Expand
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats.
Positive allosteric modulators (PAMs) of the GABAB receptor constitute a class of pharmacological agents gaining increasing attention in the alcohol research field because of their ability to… Expand
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats.
Sardinian alcohol-preferring (sP) rats have been selectively bred, over almost 40 years, for high alcohol preference and consumption. sP rats have served as an animal model for more than 120… Expand