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Computational thinking (CT) has been described as the use of abstraction, automation, and analysis in problem-solving [3]. We examine how these ways of thinking take shape for middle and high school youth in a set of NSF-supported programs. We discuss opportunities and challenges in both in-school and after-school contexts. Based on these observations, we(More)
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Progestin resistance is a major obstacle to treating early stage, well-differentiated endometrial cancer as well as recurrent endometrial cancer. The mechanism behind the suboptimal response to progestin is not well understood. The PTEN tumor suppressor gene is frequently mutated in type I endometrial cancers and this mutation results in hyperactivation of(More)
The excitement around K-12 Computing Education in the United States is rapidly increasing and K-8 holds great potential as the entry point for the integration of computing. We examine how young learners can gain early exposure and engage in rich computational experiences in K-8. These experiences can build students' computational thinking, understanding of(More)
1. SUMMARY Several changes and reforms in teaching computer science have been proposed and championed as part of the CS10K initiative [1-4]. The CS Principles (CSP) project and the overarching CS10K initiative include a public/private partnership offering curricula, curricular frameworks, professional development, online support, and a community of practice(More)
The Inter-American Dialogue is the leading U.S. center for policy analysis, exchange, and communication on issues in Western Hemisphere affairs. The Dialogue brings together public and private leaders from across the Americas to address hemispheric problems and opportunities. Together they seek to build cooperation among Western Hemisphere nations and(More)
Progestins have long been used clinically for the treatment of endometrial cancers; however, the response rates to progestin therapy vary and the molecular mechanisms behind progestin insensitivity are poorly understood. We hypothesized that in PTEN-mutated endometrial cancers, hyperactive Akt signaling downregulates progesterone receptor B (PRB)(More)
BACKGROUND Older people are increasingly "in harm's way" following human-induced disasters (HIDs). There is debate in the literature as to the relative impact of disasters on their psychological health compared with other age groups. Natural disasters and HIDs are thought to affect survivors differentially, and this may extend to older adults as a group. In(More)
Informal computer science (CS) education is currently taking shape within the myriad of social and technological solutions available to a wider audience. Increased access to low-cost mobile devices has led to the proliferation of web-based CS education programs accessible by more and more people. Online social networks further bolster the dissemination of(More)