Irene León

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This study was aimed at examining spatial learning and memory in nonoperated temporal lobe epilepsy (TLE). Twenty-five patients with a refractory epileptic focus located in the temporal lobe (10 in the right hemisphere and 15 in the left hemisphere) and 25 healthy age-matched controls performed the "Boxes Room," a virtual reality version of the holeboard.(More)
The main objective of this research was to establish the relation between age, cognitive reserve (CR), and attentional and executive functions. One hundred and sixty healthy participants aged 20 to 65 years old completed a wide battery of frontal-lobe tasks using classical tests that assess planning and control of movement, problem solving, and inhibition(More)
Cultivation of an active cognitive lifestyle, including diverse and challenging educational, occupational and cognitively-loaded leisure activities may be protective against development of dementia but the mechanisms underlying this link are not clear. We used the Lifetime Experiences Questionnaire (LEQ) to assess the structural brain correlates of(More)
The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS), analyze the internal consistency of the CRS, and(More)
OBJECTIVE Behavioral achievements are the product of brain maturation. During postnatal development, the medial temporal lobe completes its maturation, and children acquire new memory abilities. In recent years, virtual reality-based tasks have been introduced in the neuropsychology field to assess different cognitive functions. In this work, desktop(More)
SUMNIARY The effect of levodopa on the exterinally recorded preejection period (PEP), blood pressure, and heart rate was evaltuated in patienits with Parkinson's disease during the first 2 weeks of therapy and after 3 montlhs of continiuouis tlherapy. Dturing the same time periods, the response of these parameters to graded intravenious doses of dopa-minie(More)
OBJECTIVE The objective is to assess performance on virtual reality spatial memory tasks as well as classical neuropsychological tests in patients with fibromyalgia (FM). METHODS Fifteen FM patients and fifteen healthy age- and education-matched controls performed the virtual versions of the Morris water maze and the hole board (a virtual version called(More)
The Biobank and Translational Genomics core at Partners Personalized Medicine requires robust software and hardware. This Information Technology (IT) infrastructure enables the storage and transfer of large amounts of data, drives efficiencies in the laboratory, maintains data integrity from the time of consent to the time that genomic data is distributed(More)
BACKGROUND Urinary mercury concentrations are used in research exploring mercury exposure. Some theorists have proposed that autism is caused by mercury toxicity. We set out to test whether mercury concentrations in the urine of children with autism were significantly increased or decreased compared to controls or siblings. METHODS Blinded cohort analyses(More)
BACKGROUND Postoperative pulmonary and non-pulmonary complications are common problems that increase morbidity and mortality in surgical patients, even though the incidence has decreased with the increased use of protective lung ventilation strategies. Previous trials have focused on standard strategies in the intraoperative or postoperative period, but(More)