Irene Ladegaard Petersen

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CONTEXT People with severe mental illness (SMI) appear to have an elevated risk of death from cardiovascular disease, but results regarding cancer mortality are conflicting. OBJECTIVE To estimate this excess mortality and the contribution of antipsychotic medication, smoking, and social deprivation. DESIGN Retrospective cohort study. SETTING United(More)
BACKGROUND There is a paucity of data describing how general practitioners (GPs) label or record depression. AIMS To determine incidence and sociodemographic variation in GP-recorded depression diagnoses and depressive symptoms. METHOD Annual incidence rates calculated using data from 298 UK general practices between 1996 and 2006, adjusted for year of(More)
BACKGROUND In 2003, the Committee on Safety of Medicines (CSM) advised against treatment with selective serotonin reuptake inhibitors (SSRIs) other than fluoxetine in children, due to a possible increased risk of suicidal behaviour. This study examined the effects of this safety warning on general practitioners' depression diagnosing and prescription(More)
OBJECTIVES To estimate survival after a diagnosis of dementia in primary care, compared with people without dementia, and to determine incidence of dementia. DESIGN Cohort study using data from The Health Improvement Network (THIN), a primary care database. SETTING 353 general practices in the United Kingdom providing data to THIN. PARTICIPANTS All(More)
CONTEXT Serum total bilirubin levels in healthy patients reflect genetic and environmental factors that could influence the risk of developing respiratory disease. OBJECTIVE To examine the relationship between bilirubin levels and respiratory disease. DESIGN, SETTING, AND PARTICIPANTS Cohort study among 504,206 adults from a UK primary care research(More)
BACKGROUND Potential adverse effects of antidepressants during pregnancy have caused concern about their use. There are, however, very limited detailed data on patterns of antidepressant prescribing in pregnancy. OBJECTIVE To examine secular trends in prescribing during pregnancy, to assess whether pregnancy is a major determinant for stopping(More)
OBJECTIVES Few studies have investigated the incidence of eating disorders (EDs). Important questions about changes in the incidence of diagnosed disorders in recent years, disorder and gender-specific onset and case detection remain unanswered. Understanding changes in incidence is important for public health, clinical practice and service provision. The(More)
Electronic health records of longitudinal clinical data are a valuable resource for health care research. One obstacle of using databases of health records in epidemiological analyses is that general practitioners mainly record data if they are clinically relevant. We can use existing methods to handle missing data, such as multiple imputation (mi), if we(More)
OBJECTIVE To describe the contribution of primary care to the diagnosis and management of sexually transmitted infections in the United Kingdom, 1990-2000, in the context of increasing incidence of infections in genitourinary medicine clinics. DESIGN Population based study. SETTING UK primary care. PARTICIPANTS Patients registered in the UK general(More)
BACKGROUND A number of infectious agents have previously been suggested as risk factors for the development of Guillain-Barré syndrome (GBS), but robust epidemiologic evidence for these associations is lacking. METHODS AND FINDINGS We conducted a nested case-control study using data from the United Kingdom General Practice Research Database between 1991(More)