Irene Hadjikoumi

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The interrupter technique (Rint) is a noninvasive method for assessing respiratory resistance. The aims of this study were to assess whether upper airway support affects the measurement of Rint, if inspiratory or expiratory Rint were most reproducible, and which method of assessing Rint correlated best with spirometry results and was the most sensitive for(More)
OBJECTIVE To expand the clinical phenotype of autosomal dominant congenital spinal muscular atrophy with lower extremity predominance (SMA-LED) due to mutations in the dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) gene. METHODS Patients with a phenotype suggestive of a motor, non-length-dependent neuronopathy predominantly affecting the lower limbs were(More)
The common report of parents of asthmatic children that inhaled/nebulised salbutamol causes overactive behaviour was investigated. Nineteen children were assessed in a standardised setting before and after the administration of nebulised salbutamol and placebo. Neither parental report nor observer ratings suggested any significant increase in the child's(More)
BACKGROUND Advances in healthcare have improved the survival of children with neurological disabilities (ND). Studies in the US have shown that children with ND use a substantial proportion of resources in children's hospitals, however, little research has been conducted in the UK. We aimed to test the hypothesis that children with neurological disabilities(More)
INTRODUCTION Paediatric major trauma centres are being developed in the UK. As a paediatric unit within a large regional hospital that is co-located with a neurosciences centre, we conducted this study to establish what inpatient rehabilitation service is offered to patients with traumatic brain injury (TBI). It is known that early rehabilitation improves(More)
Nitric oxide (NO) is being increasingly used to assess airway inflammation in childhood. The method recommended by the American Thoracic Society workshop is for a prolonged expiration against a resistance. However, this is very difficult to apply in young children. As a result there have been a number of studies in which mixed expired gas has been collected(More)
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