Irene Bruske-Hohlfeld

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Risk factors for early onset of lung cancer are relatively unknown. In a case-control study, carried out in Germany between 1990 and 1996, the effects of smoking and familial aggregation of cancer were compared in 251 young cases and 280 young controls (< or = 45 years) and in 2,009 older cases and 2,039 older controls (55-69 years). The male/female ratio(More)
Cigarette smoking is a cause of lung cancer and other respiratory diseases. Oxidants either present in cigarette smoke and/or formed in the lung of smokers may trigger oxidative and nitrative damage to DNA and cellular components, contributing to carcinogenesis. We have used immunodot and Western blot analyses to measure nitrated (nitrotyrosine-containing)(More)
Glutathione S-transferase (GST) polymorphism may contribute to the individual variability in detoxifying lung carcinogens. This effect might be particularly relevant at low-level exposure to environmental carcinogens, such as in nonsmokers exposed to environmental tobacco smoke (ETS). We conducted a case-control study among 122 nonsmoking lung cancer cases(More)
Age- and sex-specific incidence rates of operation for suspected lumbar disc prolapse were determined for residents of Olmsted County, Minnesota, for the 30-year period 1950 through 1979. The incidence rate (adjusted to the age and sex distribution of the United States white population in 1980) was 52.3 per 100,000 person-years for all such operations and(More)
Jennifer S. Smith*, Urban Kumlin, Fredrik Nyberg, Cristina Fortes, David Zaridze, Wolfgang Ahrens, Irene Bruske-Hohlfeld, Vali Constantinescu, Jie Ting, Simone Benhamou, Lorenzo Simonato, Jens Boman, Valerie Gaborieau and Paolo Boffetta Department of Epidemiology, University of North Carolina, Chapel Hill, NC Department of Virology, University of Umeå,(More)
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