Irıs D Nagtegaal

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For several years, the lack of consensus on definition, nomenclature, natural history, and biology of serrated polyps (SPs) of the colon has created considerable confusion among pathologists. According to the latest WHO classification, the family of SPs comprises hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated(More)
High local recurrence rates were a major problem in rectal cancer treatment, with between 30 and 50 % of patients affected, resulting in a very poor quality of life and short survival of patients with rectal cancer. In recent years, prognosis of rectal cancer has markedly improved, due to innovations in surgical treatment in combination with neoadjuvant(More)
With the widespread introduction of population screening for colorectal cancer in Europe, the number of early rectal cancers is expected to increase. In the past, approximately 25 % of rectal cancers presented with early disease, defined as stage I disease. First, results from population screening in the UK demonstrate an increase to approximately 50 %(More)
Sir, We have read with great interest the article by Korkeila et al (2009) 'Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer' in a recent issue of the British Journal of Cancer. As the authors rightly state, CA-IX has been found to be of clinical value in different tumour types. The authors, however, state that their study was(More)
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