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Although hypertonic saline has been proposed as an intravenous resuscitation fluid, the beneficial effects of the sodium load are associated with potentially deleterious effects of chloride. Since the physiological lactate anion is well metabolized, hypertonic lactate solution could represent an interesting alternative. The aim of this study was to compare(More)
A satellite meeting on lactate was organized during the 8th International Symposium on Shock and Critical Care, August 2001, Bali, Indonesia. The aim of the symposium was to highlight lactate from a different standpoint to the classical view of being a prognosis marker, often solely considered by many physicians involved in intensive care medicine. The(More)
The rapid economic, scientific, and technologic development in Asia probably is the most important in the world today. Eventually, the development of health care and critical care medicine in the Western Pacific will be affected. Even with the problems that have to be faced, the future of critical care medicine in the region looks promising.However, the(More)
OBJECTIVE To compare two solutions for fluid resuscitation in post-coronary artery bypass grafting (CABG) surgery patients: Ringer's lactate (RL) versus a new solution containing half-molar sodium-lactate (HL). DESIGN Prospective randomized open label study. SETTING The first 12 h post-CABG surgery in an intensive care unit (ICU). PATIENTS There were(More)
PURPOSE OF REVIEW Cardiovascular disease is one of the most important causes of morbidity and mortality in western countries, generating an increasing number of admissions to intensive care units. Cardiac failure has long been associated with nutritional disorders, malnutrition and cachexia being frequent during the late phases of congestive heart failure:(More)
OBJECTIVE We have investigated the role of cardiopulmonary bypass on lactate metabolism in patients undergoing uncomplicated surgery for elective coronary artery bypass grafting (CABG). DESIGN Prospective non-randomized observational study. SETTINGS National Cardiovascular Center. PATIENTS. Three independent groups were studied: preoperative ( n=20),(More)
Lactate is a key metabolite that is produced by every cell and oxidized by most of them, provided that they do contain mitochondria. Its metabolism is connected to energetic homeostasis and the cellular redox state. It is well recognized as an indicator of severe outcome in severely ill patients, however, it is not a detrimental factor per se. Conversely,(More)
Mycophages were successfully isolated from lysogenic bovine strains without previous exposure to physical or chemical agents. These mycophages were exposed to 53 mycobacterial strains using ATCC 607 as an indicator strain. These strains included rapidly growing strains, human, bovine, avian, murine and BCG strains of different geographical origin.(More)
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