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This study examined the cognitive functioning of 10 treatment-resistant schizophrenic patients after a minimum of a 1-year trial on clozapine. Results indicated significant improvements on prorated Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale, Verbal, and Performance IQs and on the WAIS-R Similarities and Digit Symbol subtests. A trend was(More)
OBJECTIVE This study determined the influence of depressive symptoms on subsequent mortality of all causes. METHOD The Honolulu Heart Program, established in 1965, is a prospective, community-based cohort of Japanese American men living in Hawaii. The analysis was based on 3,196 Japanese American men aged 71-93 at the time of the fourth examination in(More)
INTRODUCTION Psychotic Disorder Following Traumatic Brain Injury (PDFTBI) is a relatively rare disorder that may provide clues to understanding schizophrenia and psychosis. The objective of this paper was to develop a conceptual framework describing how traumatic brain injury (TBI) can contribute to the development of a psychosis and potential(More)
The authors analyzed data from 69 published case studies of Psychotic Disorder Due to Traumatic Brain Injury (PDTBI) in order to describe its common characteristics and assist in its diagnosis and differentiation from schizophrenia. The majority of these PDTBI patients were males with onset of symptoms occurring within the first 2 years after moderate to(More)
Psychosis is a rare but devastating sequela of traumatic brain injury (TBI). This study examined risk factors for developing a psychosis secondary to TBI (PSTBI). Demographics of 25 inpatients with PSTBI were statistically analyzed for risk factors. Data from the PSTBI group were also compared with data from a control group of TBI patients without(More)
Neuropsychological functioning in individuals with psychotic disorder following traumatic brain injury (PDFTBI), traumatic brain injury without psychosis (TBIWP), and schizophrenia were compared against each other and to the means of normal subjects. It was predicted that the PDFTBI group would be similar to the schizophrenic group in patterns of deficits,(More)
OBJECTIVE Given that circadian rhythm disruption is associated with impairments in cognitive performance similar to those found in age-related cognitive decline, the authors investigated whether exogenous melatonin administration would improve cognitive functioning in healthy elderly subjects. METHODS This double-blind, placebo-controlled pilot study(More)
OBJECTIVE Few studies, with conflicting results, have examined the occurrence of thrombocytopenia with valproate administration. This study assessed whether the platelet-lowering effects of valproate are increased among elderly psychiatric patients. METHOD The charts of 39 psychiatric inpatients taking valproate were reviewed. Information on hematologic(More)
BACKGROUND The purpose of the authors' study was to evaluate the efficacy of methylphenidate in the medically ill depressed patients and to examine the factors that appear to affect therapeutic response and side effects. METHOD Hospital charts were reviewed for 29 patients who received trials of methylphenidate for treatment of depressive disorders while(More)