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Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical(More)
We address the issue of correspondence between classical supergravity and quantum super Yang-Mills (or Matrix theory) expressions for the long-distance, low-velocity interaction potentials between 0-branes and bound states of branes. The leading-order potentials are reproduced by the F 4 terms in the 1-loop SYM effective action. Using self-consistency(More)
tered at +120 bp, the following ones at +300 and +480, respectively. RNA POL II sits right on the TSS. In the upstream region, we observe no periodic signal indicative of regular nucleosome positioning (phasing) across promoters. The closest nucleosomes are located around position −180 leaving a minimal nucleosome-free promoter region of 150 bp. As the(More)
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin(More)
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enriched in included alternatively spliced exons (ASEs), and(More)
Whole-genome resequencing is still a costly method to detect genetic mutations that lead to altered forms of proteins and may be associated with disease development. Since the majority of disease-related single nucleotide variations (SNVs) are found in protein-coding regions, we propose to identify SNVs in expressed exons of the human genome using the(More)