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Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical(More)
We discuss long-distance, low-velocity interaction potentials for processes involving longitudinal M5-brane (corresponding in type IIA theory language to the 1/4 supersymmetric bound state of 4-brane and 0-brane). We consider the following scattering configurations: (a) D = 11 graviton off longitudinal M5-brane, or, equivalently, 0-branes off marginal 40(More)
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enriched in included alternatively spliced exons (ASEs), and(More)
Both transcription and post-transcriptional processes, such as alternative splicing, play crucial roles in controlling developmental programs in metazoans. Recently emerged RNA-seq method has brought our understanding of eukaryotic transcriptomes to a new level, because it can resolve both gene expression level and alternative splicing events(More)
We address the issue of correspondence between classical supergravity and quantum super Yang-Mills (or Matrix theory) expressions for the long-distance, low-velocity interaction potentials between 0-branes and bound states of branes. The leading-order potentials are reproduced by the F 4 terms in the 1-loop SYM effective action. Using self-consistency(More)
UNLABELLED To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genotyping of the 8p23.1 inversion in a Caucasian population. METHODS Principal components analysis (PCA) was(More)
tered at +120 bp, the following ones at +300 and +480, respectively. RNA POL II sits right on the TSS. In the upstream region, we observe no periodic signal indicative of regular nucleosome positioning (phasing) across promoters. The closest nucleosomes are located around position −180 leaving a minimal nucleosome-free promoter region of 150 bp. As the(More)