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Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical(More)
We discuss long-distance, low-velocity interaction potentials for processes involving longitudinal M5-brane (corresponding in type IIA theory language to the 1/4 supersymmetric bound state of 4-brane and 0-brane). We consider the following scattering configurations: (a) D = 11 graviton off longitudinal M5-brane, or, equivalently, 0-branes off marginal 40(More)
Both transcription and post-transcriptional processes, such as alternative splicing, play crucial roles in controlling developmental programs in metazoans. Recently emerged RNA-seq method has brought our understanding of eukaryotic transcriptomes to a new level, because it can resolve both gene expression level and alternative splicing events(More)
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enriched in included alternatively spliced exons (ASEs), and(More)
UNLABELLED To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genotyping of the 8p23.1 inversion in a Caucasian population. METHODS Principal components analysis (PCA) was(More)
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin(More)
We address the issue of correspondence between classical supergravity and quantum super Yang-Mills (or Matrix theory) expressions for the long-distance, low-velocity interaction potentials between 0-branes and bound states of branes. The leading-order potentials are reproduced by the F 4 terms in the 1-loop SYM effective action. Using self-consistency(More)