Iordanis E. Evangelou

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Glial activation in the setting of central nervous system inflammation is a key feature of the multiple sclerosis (MS) pathology. Monitoring glial activation in subjects with MS, therefore, has the potential to be informative with respect to disease activity. The translocator protein 18 kDa (TSPO) is a promising biomarker of glial activation that can be(More)
BACKGROUND AND PURPOSE Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability. MATERIALS AND METHODS Twenty-four patients with(More)
This paper presents a method for Data Mining and Knowledge Discovery in Image Data. This method is based on the Self-Organizing Map (SOM) which is an unsupervised artificial neural network algorithm. The SOM possesses unique properties of clustering, classification, modelling and visualization and is used here as a Data Mining tool. This enables us to get(More)
BACKGROUND Fatigue is a common and disabling symptom of multiple sclerosis (MS). Previous studies reported that damage of the corticostriatothalamocortical circuit is critical in its occurrence. OBJECTIVE To investigate the relationship between fatigue in MS and regional cortical and subcortical gray matter atrophy. DESIGN Case-control study. SETTING(More)
Youths with conduct disorder or oppositional defiant disorder and psychopathic traits (CD/ODD+PT) are at high risk of adult antisocial behavior and psychopathy. Neuroimaging studies demonstrate functional abnormalities in orbitofrontal cortex and the amygdala in both youths and adults with psychopathic traits. Diffusion tensor imaging in psychopathic adults(More)
BACKGROUND AND PURPOSE We investigated the impact of focal and diffuse corticospinal tracts damage on sensory-motor disability in multiple sclerosis (MS) patients. METHODS Twenty-five MS patients underwent 3.0 Tesla (3T) magnetic resonance imaging with diffusion tensor imaging (DTI). The Expanded Disability Status Scale (EDSS) and the Timed 25-Foot Walk(More)
OBJECTIVE Multiple sclerosis (MS) lesions develop around small, inflamed veins. New lesions enhance with gadolinium on magnetic resonance imaging (MRI), reflecting disruption of the blood-brain barrier (BBB). Single time point results from pathology and standard MRI cannot capture the spatiotemporal expansion of lesions. We investigated the development and(More)
BACKGROUND AND PURPOSE Using high-field magnetic resonance imaging (MRI), we investigated the relationships between white matter (WM) lesion volume (LV), normal-appearing WM (NAWM) normalized volume, WM-lesion and NAWM magnetization transfer ratios (MTRs), brain parenchyma fraction (BPF), and cognitive impairment (CI) in multiple sclerosis (MS). METHODS(More)
Citation CMS Collaboration et al. " Transverse-momentum and Pseudorapidity Distributions of Charged Hadrons in Pp Collisions at $\sqrt{s} = 0.9 $ and 2.36 TeV. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Transverse-momentum and pseudorapidity distributions of charged hadrons in pp(More)
New data are presented on charged particle pseudorapidity distributions for inelastic events produced at c.m. energies ]//s=200 and 900 GeV. The data were obtained at the CERN antiproton-proton Collider operated in a new pulsed mode. The rise of the central density p(0) at energies up to ]fs = 900 GeV has been studied. A new form of central region scaling(More)