Ioannis Manousakas

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Intensity- or edge-based methods of segmentation are often insufficiently robust to be applied to images containing complex anatomical objects, such as those seen in high-resolution magnetic resonance imaging systems. Split-and-merge techniques attempt to overcome these difficulties by using homogeneity measures. Simple modifications to the basic 2D(More)
Extracorporeal Shock Wave Therapy is a relatively new alternative method to surgery for the treatment of many bone and muscle disorders. Currently, targeting of shock waves in the human body is done using either ultrasound or x-ray imaging. Many studies have shown controversial treatment results with conclusions that criticize ultrasound targeting. Here it(More)
Collagen II and hyaluronan are the two major components of the native extracellular matrix (ECM). Both biopolymers are responsible for providing the associated tissues with tensile strength, and also serve as a structural scaffold for cell adhesion and growth. Over the years, many researchers have focused on the preparation and evaluation of man-made ECM(More)
PURPOSE We developed a real-time tracking system for renal stones that decreases the number of shock waves and treatment time of shock wave lithotripsy. MATERIALS AND METHODS Ultrasound images were analyzed to identify the renal stones. A computer software module for ultrasound image processing was developed to monitor stone location instantaneously.(More)
Extracorporeal Shock Wave Lithotriptors are very popular for the treatment of urinary stones all over the world. They depend basically upon either X-ray fluoroscopy or ultrasound scans to detect the stones before therapy begins. To increase the effectiveness of treatment this study took advantage of both X-ray and ultrasound to develop a dual stone locating(More)
PURPOSE We have previously developed and reported an ultrasound based real-time tracking system for renal stones. In the current study we continued to verify the reliability of this tracking system by a simulated animal test. MATERIALS AND METHODS We used 13 prerecorded ultrasound stone trajectories to test the system. The real-time tracking system was(More)
Although extracorporeal shock wave lithotripsy (ESWL) is the standard procedure for treating renal stones, little work has been done on ways to minimize the side effects and on treatment optimization. A system that uses ultrasound imaging for real time renal stone monitoring is presented here and some aspects of the image analysis module are described. The(More)
BACKGROUND Low-intensity pulsed ultrasound (LIPUS) regiment has been used to treat fractures with non-union and to promote bone union in general. The effect of LIPUS on articular cartilage metabolism has been characterized. Yet, the effect of LIPUS to repair articular cartilage injury remains unclear in vivo. METHODS We designed a study to investigate the(More)
PURPOSE Extracorporeal shock wave lithotripsy has been popular since the 1980s. Only 30% to 50% of the shock waves of all conventional lithotripters are focused on stones. We developed an ultrasound based, real-time stone tracking system (version 1) to improve accuracy and treatment efficiency. However, some problems remained. We revised the existing system(More)
01 The application value of three-dimensional rotational angiography of intracranial micro-aneurysms in diagnosis and treatment Aims To evaluate the diagnostic value of three-dimensional rota-tional angiography (3D-RA) of intracranial micro-aneurysms (diameter ≤ 3 mm) and provide guidance on the value of endo-vascular treatment. Materials and methods 43(More)