Ioannis M Abatzoglou

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Microplates are useful tools in chemistry, biotechnology and molecular biology. In radiobiology research, these can be also applied to assess the effect of a certain radiation dose delivered to the whole microplate, to test radio-sensitivity, radio-sensitization or radio-protection. Whether different radiation doses can be accurately applied to a single(More)
PURPOSE Postmastectomy radiation therapy (PMRT) provides major local control and survival benefits. More aggressive radiation therapy schemes may, however, be necessary in specific subgroups, provided they are safely administered. We report the tolerance and efficacy of a highly accelerated and hypofractionated regimen (HypoARC). METHODS AND MATERIALS One(More)
BACKGROUND Concurrent radiochemotherapy and altered radiotherapy fractionation are under thorough investigation in locally advanced non-small cell lung carcinoma (NSCLC). PATIENTS AND METHODS The efficacy and tolerance of hypofractionated accelerated radiochemotherapy supported with high dose (up to 1000 mg daily) amifostine cytoprotection (hypoARC) was(More)
Since the seminal publication of Babloyanz (1985), research and studies on the non linear analysis of EEG signals have clearly taken off, empowered by progress in methodology of non linear dynamics, fractals, complexity and deterministic chaos and fuelled by the hope -and sometimes optimistic “belief” that this approach could outperform linear methods in(More)
Magnetoencephalogram (MEG) recordings of 8 patients with advanced Alzheimer Disease (AD) and 9 normal individuals were obtained with a 122-channel whole head biomagnetometer SQUID (Superconductive Quantum Interference Device) to record the minute magnetic fields generated by the brain. The obtained MEG signals were analyzed using linear signal analysis(More)
We describe a technique of postoperative irradiation of skin cancer using plesiotherapy with Ir192 high dose rate microSelectron afterloading system (Nucletron, Veenendaal, Netherlands). The clinically defined area is drawn on the skin and the flexible 'skin applicator' is then orientated so that the drawn skin area is encompassed within the catheter(More)
Primary tumors of the trachea are rare. Such cases are presented with acute respiratory distress demanding immediate therapeutic intervention. Herein, we present a case of an unresectable second primary tracheal cancer treated with intraluminal brachytherapy (8 Gy at 1 cm from catheter) followed by a short course of external beam hypofractionated(More)
The AlamarBlue assay is based on fluorometric detection of metabolic mitochondrial activity of cells. In this study, we determined the methodology for application of the assay to radiation response experiments in 96-well plates. AlamarBlue was added and its reduction measured 7 hours later. Selection of the initial number of plated cells was important so(More)
AIM We evaluated the feasibility and efficacy of postoperative hypofractionated and accelerated radiotherapy supported with amifostine cytoprotection (HypoARC) in patients with high-risk or recurrent prostate cancer. PATIENTS AND METHODS Fourty-eight patients were recruited (median follow-up=41 months; range=12-84 months). Twenty-one received HypoARC(More)
OBJECTIVES Lung fibrosis is a severe complication after radiotherapy in patients with nonsmall cell lung cancer and is the main undesirable late complication limiting the therapeutic ratio of thoracic radiation treatment. Here we evaluated the lung fibrosis using computed tomography scan mediated assessment of lung tissue density in long-term survivals(More)