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Current evidence for histone deacetylase inhibitors in pancreatic cancer.

• Ioannis Koutsounas, Constantinos T. Giaginis, Efstratios S. Patsouris, Stamatios Theocharis
• World journal of gastroenterology
• 2013

Pancreatic cancer is one of the most aggressive human cancers, with more than 200 000 deaths worldwide every year. Despite recent efforts, conventional treatment approaches, such as surgery and… (More)

Pregnane X receptor and human malignancy.

• Ioannis Koutsounas, Efstratios S. Patsouris, Stamatios Theocharis
• Histology and histopathology
• 2013

Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in liver, intestine and other tissues. PXR exerts transcriptional regulation by binding to its DNA response… (More)

Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?

• Ioannis Koutsounas, Constantinos T. Giaginis, Stamatios Theocharis
• World journal of gastroenterology
• 2013

Pancreatic cancer, although not very frequent, has an exceptionally high mortality rate, making it one of the most common causes of cancer mortality in developed countries. Pancreatic cancer is… (More)

Farnesoid X Receptor (FXR) from normal to malignant state.

• Ioannis Koutsounas, Constantinos T. Giaginis, Stamatios Theocharis
• Histology and histopathology
• 2012

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose… (More)

Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease

• Giorgos Bamias, Michalis Gizis, +9 authors Spiros D Ladas
• Canadian journal of gastroenterology & hepatology
• 2016

Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. Serum DcR3 (sDcR3) levels during the chronic… (More)

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.

• Ioannis Koutsounas, Constantinos T. Giaginis, +4 authors Stamatios Theocharis
• Pancreas
• 2015

OBJECTIVES Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The present… (More)

Markers of bacterial translocation in end-stage liver disease.

• Ioannis Koutsounas, Garyfallia Kaltsa, Spyros I Siakavellas, Giorgos Bamias
• World journal of hepatology
• 2015

Bacterial translocation (BT) refers to the passage of viable bacteria or bacterial products from the intestinal lumen, through the intestinal epithelium, into the systemic circulation and… (More)

Histone deacetylase (HDAC)-1, −2, −4 and −6 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival

• Constantinos T. Giaginis, Christos Damaskos, +5 authors Stamatios Theocharis
• BMC gastroenterology
• 2015

BACKGROUND Histone deacetylases (HDACs) have been associated with malignant tumor development and progression in humans. HDAC inhibitors (HDACIs) are currently being explored as anti-cancer agents in… (More)

Pregnane X receptor (PXR) at the crossroads of human metabolism and disease.

• Ioannis Koutsounas, Stamatios Theocharis, Efstratios S. Patsouris, Constantinos T. Giaginis
• Current drug metabolism
• 2013

Pregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, is expressed in liver and intestine, as also in other tissues and cells. PXR is activated by a wide variety of… (More)

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.

• Ioannis Koutsounas, Stamatios Theocharis, Ioanna Delladetsima, Efstratios S. Patsouris, Constantinos T. Giaginis
• Expert opinion on drug metabolism & toxicology
• 2015

INTRODUCTION Farnesoid x receptor (FXR) belongs to the group of nuclear receptors (NRs), which regulate the expression of various genes by binding to DNA either as a monomer or a heterodimer with… (More)

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