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BACKGROUND The aims of the study were: first to examine, using clinical symptoms of patients as a template, whether the correlated but independent dimensions of positive, negative and depressive symptoms that have been identified in clinical psychosis, also have a distribution as non-clinical experiences in the general population; and second, to establish(More)
The aim of this study within the Athens Study of Psychosis Proneness and Incidence of Schizophrenia (ASPIS) was the examination of the latent structure of schizotypal dimensions among a large population of young male conscripts in the Greek Air Force during their first week of military training. Confirmatory factor analysis (CFA) was conducted on 1,355(More)
A population of 2,075 young men aged 18-25 years selected from the conscripts of the Greek Air Force performed an antisaccade task as part of a prospective study for the identification of risk factors in the development of psychoses. The aim of this study, which is ongoing, is to follow this population and investigate the possible predictive value of(More)
In this study we examined the performance of human subjects in three oculomotor tasks: a visually guided saccade task (VST), a simple antisaccade task (SAT) and a mirror antisaccade task (MAT). The stimulus presentation was identical for all three tasks, and the differentiation of the tasks was based on the instruction given to the subjects. Subjects were(More)
The term antisaccade refers to saccades that are performed towards the side opposite to that of target appearance. The performance of antisaccades is considered to be determined by intact frontal inhibitory areas as patients with frontal, and especially prefrontal, lesions show a striking impairment in suppressing an unwanted protarget saccade. We recorded(More)
Fifteen healthy volunteers performed a memory-pointing task using their right arm while single-pulse transcranial magnetic stimulation (TMS) above motor threshold was applied over the posterior parietal or prefrontal cortex of the left or right hemisphere in four blocks of trials. The stimulation was randomly delivered at one of three time intervals during(More)
Forty-seven normal subjects performed two-dimensional arm movements on a digitizer board using a mouse device. The movements were projected on a computer monitor. Subjects were instructed to move the mouse using the whole arm from a center position to a peripheral target so that the projected movement would pass over the target without stopping on the(More)
Premovement cortical potentials were studied with 4 types of saccadic eye movement: (a) visually triggered saccades of normal reaction time (RT; regular saccades); (b) visually triggered saccades of extremely short RT (express saccades); (c) saccades towards predicted target locations (anticipatory saccades); (d) saccades back towards predicted location of(More)
BACKGROUND Aspects of cognitive function and schizotypy have been proposed as potential endophenotypes for schizophrenia. It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia. METHODS We examined the potential impact of 18 single(More)
Antisaccade performance was investigated in a sample of 2,006 young males as part of a large epidemiological study investigating psychosis proneness. This report summarizes the effects of task parameters on performance using a sample of 55,678 antisaccade trials collected from a subpopulation of 947 individuals. Neither the amplitude nor the latency of an(More)