Ioan Tomuta

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Two chemometric methods, partial least squares regression (PLS) and principal component regression (PCR), were evaluated for the simultaneous assay of chloramphenicol, chlorhexidine and metronidazole on dissolutions samples from a mucoadhesive buccal gel formulation. A calibration set consisting of 34 mixture solutions was prepared by means of an orthogonal(More)
Indapamide (IDP) is a non-thiazide sulphonamide diuretic drug, currently used for the treatment of essential hypertension. A pharmaceutical formulation is considered appropriate when no interactions drug-excipient or excipient-excipient occur. The purpose of the present work was to study the compatibility of IDP with the pharmaceutical excipients employed(More)
BACKGROUND The granulation process of a metoprolol tartrate (very difficult to process active pharmaceutical ingredient) formulation in laboratory scale fluid bed equipment was studied. AIM To study the influence of two formulation factors and three process parameters on the characteristics of the granules and subsequently of the tablets, in the case of(More)
This work describes the development and validation of a near infrared (NIR) spectroscopy method coupled with an appropriate multivariate calibration algorithm for the simultaneous quantification of encapsulated drug, simvastatin (SIM) and excipients, L-α-phosphatidylcholine (LPC) and cholesterol (CHO) in liposomes. The development of calibration models for(More)
The objective of the present study was the development and the in vitro evaluation of extended release multiparticulate dosage forms with carbamazepine, starting from drug crystals of established granulometry as cores and using Eudragit NE aqueous dispersions as coating film polymer in a bottom spray fluid bed coating system. The chosen independent(More)
This paper describes the development and application of NIR-chemometric methods for active content assay and pharmaceutical characterization (granulometric analysis and flowability assessment) of indapamide powder blends for tabletting. Indapamide powder blends were prepared and their NIR spectra were recorded in reflectance mode. Partial least-squares(More)
Quality by design principles (QbD) were used to assist the formulation of prednisolone-loaded long-circulating liposomes (LCL-PLP) in order to gain a more comprehensive understanding of the preparation process. This approach enables us to improve the final product quality in terms of liposomal drug concentration, encapsulation efficiency and size, and to(More)
Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumor. In this work, liposomes with(More)
This paper describes the development and validation of a multivariate method based on transmittance NIR spectroscopy for simultaneous quantification of l-α-phosphatidylcholine (LPC) and cholesterol (CHO). Method development was based on a D-optimal experimental design consisting of 16 LPC-CHO mixtures. Calibration models were generated by partial(More)
A NIR-chemometric method, that is able to directly quantify the active pharmaceutical ingredient (API) and two major excipients in pharmaceutical powder blends for manufacturing indapamide sustained release (SR) tablets, was developed and fully validated. In order to develop calibration models for the assay of indapamide, hydroxypropylmehylcelulose (HPMC)(More)