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Through its involvement in inflammation, opsonization, and cytolysis, the complement protects against infectious agents. Although most of the complement proteins are synthesized in the central nervous system (CNS), the role of the complement system in the normal or ischemic CNS remains unclear. Here we demonstrate for the first time that neural progenitor(More)
Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is the hallmark of reactive(More)
The function of the normal conformational isoform of prion protein, PrP(C), remains unclear although lines of research have suggested a role in the cellular response to oxidative stress. Here we investigate the expression of PrP(C) in hypoxic brain tissues to examine whether PrP(C) is in part regulated by neuronal stress. Cases of adult cerebral ischemia(More)
BACKGROUND Medical education has been characterized in terms of points of transition, which are accentuated by lack of relevant prior experience and can lead to extreme positive and negative emotions. AIMS Quantify the effect of maturity on medical students' transitions into the clinical environment and identify how experiences of transition might be(More)
Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C57/BLIcrfa(t) mice. Slices were subjected(More)
A curriculum knowledgebase, based on a visual model and ontology, is presented part way through its development lifecycle. The early modelling stages have yielded a means to tackle the complex curriculum structure, an operational knowledgebase and consensus among the domain experts on the ways in which the academic curriculum development team, students and(More)
Personal and Professional Development (PPD) is now key to the undergraduate medical curriculum and requires provision of appropriate learning experiences. In order to achieve this, it is essential that we ascertain students' perceptions of what is important in their PPD. We required a methodological approach suitable for a large medical school, which(More)
The nuclei of cells from the supraoptic nucleus (SON) of virgin female C57BL/lcrfat mice, ranging from eight to thirty-two months of age, were studied by electron microscopy. A quantitative study has shown that the frequency of membranous and fibrillar inclusions within the cell nuclei increase with age, but the membranous inclusions decline at extreme age,(More)
On décrit quelques caractéristiques biochimiques et immunologiques des «ghosts» de cellules de la tumeur ascitique d'Ehrlich, produits par une méthode facile de lyse hypotonique. Ces «ghosts» ne forment pas de tumeurs quand on les injecte aux souris par voie i.p. et ils protègent celles-ci contre les cellules EAT viables.