Inna Zelljadt

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Virus particles morphologically similar to the known oncogenic RNA-type viruses have been isolated and cultured from a spontaneous mammary carcinoma of a rhesus monkey. The virus was initially isolated by cocultivation of tumor tis sues with monkey embryonic cell cultures but was later found to be transmissible as a cell-free filtrate. The virus is(More)
4 presumptive clastogens (caffeine, dimethyl sulfoxide, diethylstilbestrol and p,p'-DDE) and 4 chemicals thought to induce chromosomal mutations in L5178Y mouse lymphoma cells (procarbazine X HCl, epichlorohydrin, hycanthone and iodomethane) were tested in the CHO/HGPRT gene mutation assay for the induction of 6-thioguanine-resistant ( 6TGR ) mutants. Of(More)
Nine chemicals classified as presumptive carcinogens on the basis of chronic rodent bioassays and one suspected human carcinogen which are reportedly not mutagenic to Salmonella typhimurium tester strains were tested for the ability to produce morphological transformation in Syrian hamster embryo cells in the absence of any exogenous source of metabolic(More)
Efficacious systems are described for the large-scale growth in tissue culture and concentration of infectious (P3HR-1) and transforming (B95-8) Epstein-Barr virus. Also recorded here are our updated procedures for growing stock cultures and protocols to harvest fluids containing biologically active virus which is infectious or transforming. Various methods(More)