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Clinical trials demonstrated that D-serine administration improves schizophrenia symptoms, raising the possibility that altered levels of endogenous D-serine may contribute to the N-methyl… (More)
Mammalian brain contains high levels of d-serine, an endogenous co-agonist of N-methyl D-aspartate type of glutamate receptors. D-Serine is synthesized by serine racemase, a brain enriched enzyme… (More)
Abstract Mammalian brain contains high levels of d-serine, an endogenous co-agonist of N-methyl d-aspartate type of glutamate receptors. d-Serine is synthesized by serine racemase, a brain enriched… (More)
Mammalian serine racemase is a brain-enriched enzyme that converts L- into D-serine in the nervous system. D-Serine is an endogenous co-agonist at the "glycine site" of N-methyl D-aspartate (NMDA)… (More)