Ingrid Titlestad

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BACKGROUND AND OBJECTIVES The aim of this work was to determine the prevalence of antibodies to hepatitis B core antigen (anti-HBc) among Danish blood donors and to correlate this with risk factors for blood-borne and sexually transmitted diseases. MATERIALS AND METHODS During a 5-month period, 10 862 consecutive donors in the County of Funen were(More)
We investigated the effect of daily real-time teleconsultations for one week between hospital-based nurses specialised in respiratory diseases and patients with severe COPD discharged after acute exacerbation. Patients admitted with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) at two hospitals were recruited at hospital discharge.(More)
Chronic obstructive pulmonary disease (COPD) is, according to the WHO, the fifth leading cause of death worldwide, and is expected to increase to rank third in 2030. Few robust biomarkers for COPD exist, and several attempts have been made to find suitable molecular marker candidates. One rising research area is breath analysis, with several published(More)
BACKGROUND Microfibrillar-associated protein 4 (MFAP4) is a matricellular glycoprotein that co-localises with elastic fibres and is highly expressed in the lungs. The aim of this study was to test the hypothesis that plasma MFAP4 (pMFAP4) reflects clinical outcomes in chronic obstructive pulmonary disease (COPD). METHODS pMFAP4 was measured by an(More)
Previous studies on primary spontaneous pneumothorax reported variable recurrence rates, but they were based on heterogeneous patient populations including secondary pneumothorax. We investigated young patients with primary spontaneous pneumothorax exclusively and used a national registry to track readmissions and calculate independent predictors of(More)
UNLABELLED Implementation of noninvasive ventilation (NIV) as an add-on treatment has been routinely used in a non-intensive care setting since 2004 for patients with chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure at a university hospital in Denmark. Although randomized controlled trials show lowered mortality rates(More)
INTRODUCTION Non Invasive Ventilation (NIV) has been shown to lower the mortality rate from 22% to 9% when given as an additional treatment to selected chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure and hypercapnia. Risk of intubation has been shown to fall from 33% to 14%. In February 2004 NIV was added as a treatment(More)
INTRODUCTION We performed an audit on all admissions with chronic obstructive pulmonary disease (COPD) in ex-acerbation to the Department of Emergency Medicine, Odense University Hospital (DEM) in the second half of 2012 to evaluate if an organisational change had altered visitation, treatment, initiation of non-invasive ventilation (NIV) and monitoring. We(More)
BACKGROUND There is a pressing need for new forms of treatment for COPD. Based on the known pathophysiology of COPD, inhibition of matrix metalloproteinases is a theoretically promising approach. This Phase IIa study evaluated the effects of AZD1236, a selective MMP-9 and MMP-12 inhibitor, on the biomarkers of inflammation and emphysematous lung tissue(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. We investigated whether high plasma(More)