Ingrid R. Vetter

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The guanine nucleotide-binding switch in three dimensions.

Guanine nucleotide-binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as… (More)

The complete DNA sequence of yeast chromosome III

Stephen G. Oliver, Quirina J. M. van der Aart, +143 authors John G Sgouros
Nature
1992

The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The… (More)

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

Ingrid R. Vetter, Christine Nowak, Takeharu Nishimoto, J. L. Kuhlmann, Alfred Wittinghofer
Nature
1999

The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell: Ran-binding proteins, which have a role in terminating export processes from the nucleus to the… (More)

The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller

Louis Renault, Nicolas Nassar, +4 authors Alfred Wittinghofer
Nature
1998

The gene encoding the regulator of chromosome condensation (RCC1) was cloned by virtue of its ability to complement the temperature-sensitive phenotype of the hamster cell line tsBN2, which undergoes… (More)

The pseudo GTPase CENP-M drives human kinetochore assembly

Federica Basilico, Stefano Maffini, +15 authors Andrea Musacchio
eLife
2014

Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division. The configuration and… (More)

Structure-function relationships of the G domain, a canonical switch motif.

Alfred Wittinghofer, Ingrid R. Vetter
Annual review of biochemistry
2011

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The common principle is… (More)

RanGAP mediates GTP hydrolysis without an arginine finger

Michael J. Seewald, Carolin Koerner, Alfred Wittinghofer, Ingrid R. Vetter
Nature
2002

GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP… (More)

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

Shehab A. Ismail, Ingrid R. Vetter, Begoña Sot, Alfred Wittinghofer
Cell
2010

Arfs are small G proteins that have a key role in vesicle trafficking and cytoskeletal remodeling. ArfGAP proteins stimulate Arf intrinsic GTP hydrolysis by a mechanism that is still unresolved.… (More)

Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast.

Gerd Mannhaupt, Ralf Schnall, Vadim Karpov, Ingrid R. Vetter, Heinz Feldmann
FEBS letters
1999

We identified a new, unique upstream activating sequence (5'-GGTGGCAAA-3') in the promoters of 26 out of the 32 proteasomal yeast genes characterized to date, which we propose to call… (More)

Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.

Guojing Yang, Ciro Cecconi, +6 authors C. Bustamante
Proceedings of the National Academy of Sciences…
2000

Recent advances in single molecule manipulation methods offer a novel approach to investigating the protein folding problem. These studies usually are done on molecules that are naturally organized… (More)

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