Ingrid M. Linke

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The cellular origin of preneoplastic subpopulations in liver during chemical carcinogenesis has not yet been clarified. An experimental approach to this problem became possible by using female phenotypic mosaics caused by the X-chromosome inactivation ("lyonization") occuring early in embryogenesis. Allozymes of the X-linked enzyme phosphoglycerate kinase(More)
Mouse aggregation chimaeras were produced by aggregating C3H/HeH and C3H/HeHa-Pgk-1a/Ws embryos. At mid-term the proportions of the two cell populations in these conceptuses and the X-inactivation mosaic female progeny of C3H/HeH female X C3H/HeHa-Pgk-1a/Ws male matings were estimated using quantitative electrophoresis of phosphoglycerate kinase (PGK-1)(More)
Experimental conditions are discussed that are necessary for a useful application of genetically marked laboratory animals to distinguish between clonal and nonclonal origin of induced tumors: quantitative discrimination of biochemical markers, definition of the "patch" sizes, evaluation of possible admixture of "contaminating" cells and the approach to(More)