Jan Hillert13
Lars Alfredsson12
13Jan Hillert
12Lars Alfredsson
7Jenny Link
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Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially(More)
BACKGROUND The recently described interaction between smoking, human leukocyte antigen (HLA) DRB1*15 and absence of HLA-A*02 with regard to multiple sclerosis (MS) risk shows that the risk conveyed by smoking differs depending on genetic background. We aimed to investigate whether a similar interaction exists between passive smoking and HLA genotype. (More)
  • Ashley H Beecham, Nikolaos A Patsopoulos, Dionysia K Xifara, Mary F Davis, Anu Kemppinen, Chris Cotsapas +187 others
  • 2013
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802(More)
BACKGROUND The anti-JC virus (JCV) antibody status has been introduced to stratify patients with multiple sclerosis (MS) for higher or lower risk of progressive multifocal leukoencephalopathy (PML). OBJECTIVE To assess the potential utility of anti-JCV antibody levels for earlier diagnosis or prediction of PML. METHODS An analytically validated antibody(More)
  • Ellen Iacobaeus, Petra Amoudruz, Mikael Ström, Mohsen Khademi, Lou Brundin, Jan Hillert +5 others
  • 2011
BACKGROUND Most patients with relapsing-remitting multiple sclerosis (RRMS) eventually enter a secondary progressive (SPMS) phase, characterized by increasing neurological disability. The mechanisms underlying transition to SPMS are unknown and effective treatments and biomarkers are lacking. Vascular endothelial growth factor-A (VEGF-A) is an angiogenic(More)
Translational research typically aims to identify and functionally validate individual, disease-specific genes. However, reaching this aim is complicated by the involvement of thousands of genes in common diseases, and that many of those genes are pleiotropic, that is, shared by several diseases. We integrated genomic meta-analyses with prospective clinical(More)
  • Anna L. Mitchell, Katie D. R. Macarthur, Earn H. Gan, Lucy E. Baggott, Anette S. B. Wolff, Beate Skinningsrud +30 others
  • 2014
BACKGROUND Gene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component to disease susceptibility has yet to be accounted for. AIM To investigate the role of 19 candidate genes in AAD susceptibility in six(More)
  • Anna Karin Hedström, Izaura Lima Bomfim, Lisa Barcellos, Milena Gianfrancesco, Catherine Schaefer, Ingrid Kockum +2 others
  • 2014
OBJECTIVE We investigated potential interactions between human leukocyte antigen (HLA) genotype and body mass index (BMI) status in relation to the risk of developing multiple sclerosis (MS). METHODS We used 2 case-control studies, one with incident cases (1,510 cases, 2,017 controls) and one with prevalent cases (937 cases, 609 controls). Subjects with(More)
  • Inger-Lise Mero, Marte W. Gustavsen, Hanne S. Sæther, Siri T. Flåm, Pål Berg-Hansen, Helle B. Søndergaard +16 others
  • 2013
The presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) is a typical finding in multiple sclerosis (MS). We applied data from Norwegian, Swedish and Danish (i.e. Scandinavian) MS patients from a genome-wide association study (GWAS) to search for genetic differences in MS relating to OCB status. GWAS data was compared in 1367 OCB positive and(More)
  • Agne Liedén, Mårten C. G. Winge, Annika Sääf, Ingrid Kockum, Elisabeth Ekelund, Elke Rodriguez +9 others
  • 2012
BACKGROUND Atopic dermatitis (AD) is a common chronic inflammatory skin disorder where epidermal barrier dysfunction is a major factor in the pathogenesis. The identification of AD susceptibility genes related to barrier dysfunction is therefore of importance. The epidermal transglutaminases (TGM1, TGM3 and TGM5) encodes essential cross-linking enzymes in(More)