Ingram Iaccarino

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AbstractEctopic expression of c-myc sensitises cells to a wide range of apoptotic stimuli by inducing the release of cytochrome c from the mitochondrial intermembrane space into the cytosol. To elucidate the molecular mechanisms of mitochondrial permeabilisation in response to c-Myc activation, we carried out a biochemical fractionation analysis of Rat1(More)
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas(More)
Glucose 6-phosphate dehydrogenase (G6PD) (EC 1.1.1.42) is an essential enzyme for the rapid production of NADPH, as required on exposure to oxidative stress. Mouse embryonic stem (ES) cells can produce all embryonic and fetal/adult cell types. By studying the in vitro differentiation of embryoid bodies produced from G6pdDelta ES cells that are totally(More)
AbstractGlucose-6-phosphate dehydrogenase-deleted embryonic stem (ES) cells (G6pdΔ) proliferate in vitro without special requirements, but when challenged with oxidants fail to sustain glutathione disulphide reconversion to reduced glutathione (GSH), entering a condition of oxidative stress. Here, we investigate the signalling events downstream of GSH(More)
Alterations in several aspects of cell metabolism have recently been re-discovered as one of the main features of most cancer cells. The three minireviews discuss how alterations in the glycolytic pathway, in lipid metabolism and in amino acid sensing may give a growth advantage to cells with high proliferative rates, experiencing inadequate nutrients(More)
Living standards have increased across the world. In particular, in strong economies, such as China, India and Brazil, a significant increase in life expectancy is likely to follow. The increase in the aged population is likely to result in an increased incidence of cancer. Although little in cancer treatment has changed in the last 20 years, significant(More)
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