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Effects of centrally (intracerebro-ventricularly) administered synthetic substance P on the metabolism of cAMP in 19 brain areas were investigated. Substance P administration increased cAMP levels considerably in the frontal cortex, the central gray matter and in the nucleus of the solitary tract, and to a lesser extent in the bed nucleus of the stria(More)
Actions of the central angiotensin system on brain cAMP concentrations were studied after intraventricular injection of renin. Biosynthesis of endogenous brain angiotensin II was stimulated by 0.1 U renin and the blood pressure was elevated 40 min after the application. Stimulation of the brain angiotensin system affected cAMP metabolism in several brain(More)
Juvenile dermatomyositis (JDM) is a chronic inflamma-tory disorder, which primarily affects muscle and skin. Patients usually present with progressive muscle weakness accompanied by an erythematous rash over the joints and across the face. Articular, cardiac, pulmonary, and gas-trointestinal manifestations may occur resulting in severe morbidity. We report(More)
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