Ingo Lange

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TRPM2 is a Ca 2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca 2+ influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extra-and intracellularly and causes increases in intracellular calcium concentration ([Ca 2+ ](More)
Neuroblastoma (NB) is the most common extracranial pediatric tumor. NB patients over 18 months of age at the time of diagnosis are often in the later stages of the disease, present with widespread dissemination, and often possess MYCN tumor gene amplification. MYCN is a transcription factor that regulates the expression of a number of genes including(More)
Neuroblastoma is an extra-cranial solid cancer in children. MYCN gene amplification is a prognostic indicator of poor outcome in neuroblastoma. Recent studies have shown that the multiple steps involved in cell migration are dependent on the availability of intracellular calcium (Ca(2+)). Although significant advances have been made in understanding the(More)
Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca 2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H 2 O 2) evokes Ca 2+ influx through TRPM2 to activate(More)
2009 " Prudent princes [should] regard not only present troubles, but also future ones, for which they must prepare with every energy, because, when foreseen, it is easy to remedy them. Acknowledgements First and foremost, I would like to thank Prof. Dr. Paul Schönsleben and Prof. Markus Bärtschi for creating the open and constructive environment at the BWI(More)
Calcium signaling in phagocytes is essential for cellular activation, migration, and the potential resolution of infection or inflammation. The generation of reactive oxygen species (ROS) via activation of NADPH (nicotinamide adenine dinucleotide phosphate)-oxidase activity in macrophages has been linked to altered intracellular calcium concentrations.(More)
Companies and their customers are increasingly looking for new solutions to streamline and improve their operations. Maintenance, which can account for in between 15 - 70% of production costs is a key area of improvement in many industries. 'When the equipment will fail' and 'due to what type of failures' are critical information toward achieving effective(More)
Within the context of the EU-Project InCoCo-`S`, one of the key aims is to standardize integrative industrial service processes in order to facilitate transparency on service operation performance and the resulting customer benefit. Therefore the Service Performance Measurement System (SPMS) has been developed in order to quantify both the efficiency and(More)
Effective neuroblastoma (NB) treatments are still limited despite treatment options available today. Therefore, this study attempted to identify novel plant extracts that have anticancer effects. Cytotoxicity and increased intracellular calcium levels were determined using the Sulforhodamine B (SRB) assay and Fluo4-AM (acetoxymethyl) staining and(More)
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