Ingo Lange

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Neuroblastoma is an extra-cranial solid cancer in children. MYCN gene amplification is a prognostic indicator of poor outcome in neuroblastoma. Recent studies have shown that the multiple steps involved in cell migration are dependent on the availability of intracellular calcium (Ca(2+)). Although significant advances have been made in understanding the(More)
Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca 2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H 2 O 2) evokes Ca 2+ influx through TRPM2 to activate(More)
Within the context of the EU-Project InCoCo-`S`, one of the key aims is to standardize integrative industrial service processes in order to facilitate transparency on service operation performance and the resulting customer benefit. Therefore the Service Performance Measurement System (SPMS) has been developed in order to quantify both the efficiency and(More)
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