Ingo Hofmann

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DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these underlying maintenance mechanisms. Bru1(More)
SU(VAR)3-9 like histone methyltransferases control heterochromatic domains in eukaryotes. In Arabidopsis, 10 SUVH genes encode SU(VAR)3-9 homologues where SUVH1, SUVH2 and SUVH4 (KRYPTONITE) represent distinct subgroups of SUVH genes. Loss of SUVH1 and SUVH4 causes weak reduction of heterochromatic histone H3K9 dimethylation, whereas in SUVH2 null plants(More)
The SU(VAR)3-9 protein family was first identified in animals as heterochromatin-associated proteins and found to control establishment of heterochromatic chromatin domains by histone H3 lysine 9 methylation. In Arabidopsis ten SU(VAR)3-9 homologous SUVH genes are found where SUVH1, SUVH2 and SUVH4 represent different subgroups of genes. Also the SUVH1,(More)
Non-woven cellulose II fabrics were used as scaffolds for in vitro cartilage tissue engineering. The scaffolds were activated in a saturated Ca(OH)(2) solution and subsequently coated with a calcium phosphate layer precipitated from a supersaturated physiological solution. Chondrocyte cell response and cartilage development were investigated. The cell(More)
In a particle accelerator with a periodic structure beam space charge force may excite resonant beam emittance growth if the particle's transverse phase advance approaches 90 degrees . A recent simulation study with the PARMILA code [D. Jeon, Phys. Rev. ST Accel. Beams 12, 054204 (2009)]10.1103/PhysRevSTAB.12.054204 has shown the feasibility of measuring(More)
The existence of a structural resonance stop band caused by space charge in high-current beams, where the resonance frequency is associated with 90° phase advance per focusing period, is well known and alternatively referred to in the literature as envelope instability or as fourth-order resonance. We show, however, that this stop band is actually a(More)
Energy exchange between the longitudinal and transverse degrees of freedom of nonequipartitioned bunched beams (non-neutral plasmas) is investigated by means of 3D simulation. It is found that collective instability may lead to energy transfer in the direction of equipartition, without full progression to it, in certain bounded regions of parameter space(More)
Experimental data on emittance exchange by the space charge driven “Montague resonance” have been obtained at the CERN Proton Synchrotron in 2002-04 as a function of the working point. These data are used to advance the benchmarking of major simulation codes (ACCSIM, IMPACT, MICROMAP, ORBIT, SIMBAD, SIMPSONS, SYNERGIA) currently employed world-wide in the(More)
As a first step of a space charge nonlinear resonance benchmarking experiment over a large number of turns, beam loss and emittance evolution were measured over 1 s on a 1.4 GeV kinetic energy flat-bottom in the presence of a single octupole. By lowering the working point towards the resonance a gradual transition from a loss-free core emittance blow-up to(More)
The longitudinal coupling impedance of a cylindrical beam pipe for arbitrary relativistic gamma(0) and mode frequency is obtained analytically for finite wall conductivity and finite wall thickness. Closed form expressions for the electromagnetic fields excited by a beam perturbation are derived analytically. General expressions for the resistive-wall(More)