Ingo Alexander Grafe

Learn More
Previously, we reported significantly reduced pain and improved mobility persisting for 6 months after kyphoplasty of chronically painful osteoporotic vertebral fractures in the first prospective controlled trial. Since improvement of spinal biomechanics by restoration of vertebral morphology may affect the incidence of fracture, long-term clinical benefit(More)
UNLABELLED This study investigates the effects of kyphoplasty on pain and mobility in patients with osteoporosis and painful vertebral fractures compared with conventional medical management. INTRODUCTION Pharmacological treatment of patients with primary osteoporosis does not prevent pain and impaired activity of patients with painful vertebral(More)
STUDY DESIGN A comparative prospective trial evaluating 3-year outcome. OBJECTIVE To compare clinical and morphologic outcomes as well as follow-up fractures after kyphoplasty of painful osteoporotic vertebral fractures with calcium-phosphate (CaP) cement (group 1) and with polymethylmethacrylate (PMMA)-cement (group 2). SUMMARY OF BACKGROUND DATA CaP(More)
PURPOSE Kyphoplasty immediately improves pain and mobility in patients with painful osteoporotic vertebral fractures, but long-term clinical outcomes are still unclear. This controlled trial evaluates pain, mobility and fracture incidence 3 years after kyphoplasty. MATERIALS AND METHODS Kyphoplasty was performed in 40 patients with painful osteoporotic(More)
BACKGROUND Secondary and tertiary hyperparathyroidism are features of chronic renal disease. Although pharmacological options are available, parathyroid surgery remains the treatment of choice in these patients with worsening renal osteodystrophy or hypercalcemia. The development of thyrotoxicosis after parathyroid surgery in these patients has been rarely(More)
BACKGROUND This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. METHODS We assessed pain, disability and radiomorphological parameters by visual analogue scale (VAS 0-100), Oswestry(More)
STUDY DESIGN Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial. OBJECTIVE This study investigates long-term radiomorphologic features of intraosseous CaP cement(More)
This study investigated the prevalence of the intravertebral vacuum phenomenon (IVP) and osteonecroses in vertebral compression fractures (VCFs). We therefore performed an histological analysis of biopsies obtained from VCFs prior to balloon kyphoplasty. Computed tomography (CT) scans were reviewed regarding the presence of an IVP (i.e. cleft sign, Kümmell(More)
OBJECTIVE Lowering LDL-cholesterol by statins has been proven to be associated with reduction of proinflammatory regulators e.g. activation of the transcription factor NF-κB. To our knowledge, anti-inflammatory potential of newer cholesterol lowering agents such as ezetimibe is less intensively studied. Therefore we analyzed the effects of equipotent(More)
BACKGROUND Calcium phosphate cements are used frequently in orthopedic and dental surgeries. Strontium-containing drugs serve as systemic osteoblast-activating medication in various clinical settings promoting mechanical stability of the osteoporotic bone. METHODS Strontium-containing calcium phosphate cement (SPC) and calcium phosphate cement (CPC) were(More)