• Publications
  • Influence
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease isExpand
  • 155
  • 7
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
Loss of the CDKN2A tumor suppressor is associated with melanoma metastasis, but the mechanisms connecting the phenomena are unknown. Using CRISPR-Cas9 to engineer a cellular model of melanomaExpand
  • 40
  • 1
Systemic Treatment Options for Brain Metastases from Non-Small-Cell Lung Cancer.
Brain metastases are common in patients with non-small-cell lung cancer (NSCLC). Because of associated poor prognosis and limited specific treatment options, there is a real need for the developmentExpand
  • 6
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease isExpand
  • 5
Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
This corrects the article DOI: 10.1038/nature24302
  • 5
Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
In this Article, the sentence: “After 7 months of HFD, MUP-uPA mice developed HCC15, which contained numerous (usually 50–100 per tumour) non-recurrent coding mutations in pathways that are mutatedExpand
  • 1
Abstract 2247: Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness
Many cancers are refractory to immune checkpoint therapy (ICT), but the causes of ICT resistance remain unknown. Despite low mutational burden, hepatocellular carcinoma (HCC) responds to PD-1Expand
Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation
Significance T cells recognize their targets via their T-cell receptors (TCRs), which in the case of CD8+ T cells bind to MHC-I:antigen complexes on the surface of target cells. Many cancer cellsExpand
Abstract 2247: Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness
Many cancers are refractory to immune checkpoint therapy (ICT), but the causes of ICT resistance remain unknown. Despite low mutational burden, hepatocellular carcinoma (HCC) responds to PD-1Expand
Abstract 5518: Bi-allelic loss of CDKN2A initiates melanoma invasion and metastasis via E2F1-BRN2 axis
CDKN2A acts as a critical tumor suppressor in melanoma, as evidenced by frequent loss of function mutations and deletion. Loss of CDKN2A is believed to permit escape from senescent pre-neoplasticExpand