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The purpose of this study was to describe the prenatal formation of the human mandibular canal. Since bony canals develop in prenatal life around the nerve paths, it was assumed that the canal pattern could reflect the pattern of innervation of the dentition. Mapping of this early canal pattern does not appear to have been undertaken before. The material(More)
Developing teeth of 32 human fetuses (crown-rump length 11-205 mm) were examined immunohistochemically by antisera to protein gene product 9.5 (PGP 9.5) in an attempt to shed light upon the possible role of innervation in odontogenesis. As a control for the specificity of PGP 9.5 as a neuronal marker, the results were verified by immunocytochemical(More)
  • I Kjaer
  • 1995
A survey is given of current knowledge of the interrelationship between facial, cranial and brain development in humans. First, normal facial, cranial (mandible, maxilla, palatine bone, cranial base, theca cranii, dentition), and brain development are described separately. Then, developmental interrelationships are illustrated under normal and pathologic(More)
Williams syndrome (WS) is a rare congenital neurodevelopmental disorder with distinctive facial features, cardiovascular abnormalities, short stature, mental retardation, and behaviour and cognitive characteristics. The aim of this study was to describe the neurocranial morphology and growth in a group of 62 individuals with WS. The neurocranium was(More)
The purpose of this study was to describe in 49 normal human prenatal specimens, 15-156 mm crown-rump length (CRL), the histomorphological development of the bilateral vomeronasal organ localized in the mucosa of the nasal septum. In addition, immunohistochemical localization of luteinizing hormone-releasing hormone (LHRH) was undertaken. The material was(More)
The purpose of the present study was to investigate persistent primary second molars in a group of young people in their late twenties with agenesis of one or two second premolars. In 1982-83 it was decided, in connection with the orthodontic evaluation of 25 patients, to allow 35 primary molars (one or two in each patient) to remain in situ. All patients(More)
The present study describes the cervical column as related to head posture, cranial base, and mandibular condylar hypoplasia. Two groups were included in the study. The 'normal' sample comprised 21 subjects, 15 females aged 23-40 years (mean 29.2 years), and six males aged 25-44 years (mean 32.8 years) with neutral occlusion and normal craniofacial(More)
A previous study has demonstrated that luteinizing hormone-releasing hormone (LHRH) is localized in the human bilateral vomeronasal organs in the nasal septum during a 4-week period of intrauterine life (22). The purpose of the present study was to elucidate the location of LHRH-expressing cells outside the vomeronasal organs, with special emphasis on the(More)
The eruption mechanism is not fully understood. It is known that the dental follicle is essential and that experimentally provoked denervation influence the process of eruption. Accordingly, the purpose of this study was to elucidate the eruption pattern in a human population and relate this pattern to the pattern of jaw innervation. The eruption pattern(More)
The purpose of the present study was to analyze the linear dimensions of the cranial base and the anterior facial heights in the median plane of human fetal crania during the second trimester. The distances measured were related to gestational age (GA), crown-rump length (CRL) and maturation stages of the cranial base (MSS). The material comprised(More)