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To determine the relationship between 5-fluorouracil (FUra) toxicity and its RNA- and DNA-directed actions we examined the ability of continuous SC infusion with uridine (Urd), thymidine (dThd), or deoxyuridine (dUrd) to rescue mice from the lethal toxicity of FUra. Male B6D2F1 mice were treated with a single IP injection of FUra (800 mg/kg) followed in 24(More)
We examined the ability of uridine to increase the therapeutic index of 5-fluorouracil (FUra) against C57BL/6 X DBA/2 F1 mice bearing a Day 1 B16 melanoma or L1210 leukemia. FUra (400, 600, or 800 mg/kg, i.p.) followed in 24 hr by a 5-day s.c. infusion with uridine (5 g/kg/day, s.c.) was compared with the maximum tolerated dose of FUra (200 mg/kg, i.p.)(More)
The effect of pretreatment of rats with 5-fluorouracil (5-FU) on hepatic drug-metabolizing enzyme activities was examined. Male rats, weighing 165g, were given a single i.p. injection of 5-FU, 120 mg/kg, and 7 days later the drug-metabolizing enzyme activities of a 10,000 x g supernatant fraction from liver homogenates were exam ined. Aniline hydroxylase,(More)
We examined the effect of concurrent SC infusion of calcium leucovorin (LV) on the action of 5-fluorouracil (FUra) against mouse L1210 leukemia implanted either SC or IP. Mice bearing the SC tumor treated with FUra (100 mg/kg, IP, day 1) plus infusion with either LV (11.5 mg · kg-1 · day-1, days 1–4), or 0.9% NaCl (days 1–4) resulted in an identical(More)