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Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.
In Alzheimer's disease, paired helical filaments composed mainly of abnormally phosphorylated tau accumulate in certain selected neurons of the brain, and microtubules are rarely seen in the affectedExpand
Dyrk 1 A regulate the alternative splicing of tau exon 10 1 Dual-specificity tyrosine-phosphorylated and regulated kinase 1 A ( Dyrk 1 A ) modulates serine-arginine rich protein 55 ( SRp 55
Background: Dysregulation of the alternative splicing of tau exon 10 causes several types of neurodegenerative diseases. Results: SRp55 promotes tau exon 10 inclusion. Dyrk1A interacts with SRp55,Expand