Inge Derese

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OBJECTIVE Increasing evidence implicates mitochondrial dysfunction as an early, important event in the pathogenesis of critical illness-induced multiple organ failure. We previously demonstrated that prevention of hyperglycemia limits damage to mitochondria in vital organs, thereby reducing morbidity and mortality. We now hypothesize that inadequate(More)
Progression of ankylosis in patients with ankylosing spondylitis is highly variable. This suggests that ankylosis is at least partially due to genetic factors. We used the ankylosing enthesits model in DBA/1 mice to search for associated genes. Male DBA/1 were crossed with female BALB/c mice. Male F2 mice from different litters were studied by(More)