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Parkinson's disease and age: The obvious but largely unexplored link
Parkinson's disease is a chronic, progressive neurodegenerative disorder with increased prevalence in the aging population. It is estimated that approximately 1.5 million individuals in the US aloneExpand
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LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation
Although mutations in the leucine‐rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic Parkinson's disease, their function is largely unknown. LRRK2 is pleiotropic in nature, shownExpand
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microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
The last decade has experienced the emergence of microRNAs as a key molecular tool for the diagnosis and prognosis of human diseases. Although the focus has mostly been on cancer, neurodegenerativeExpand
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PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons
Parkinson's disease (PD) is a progressive and irreversible neurodegenerative disorder coupled to selective degeneration of dopamine‐producing neurons in the substantia nigra. The majority of PDExpand
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Emerging facets of plastid division regulation
Plastids are complex organelles that are integrated into the plant host cell where they differentiate and divide in tune with plant differentiation and development. In line with their prokaryoticExpand
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Combinatory microRNA serum signatures as classifiers of Parkinson's disease.
INTRODUCTION As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulatingExpand
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Arabidopsis AtPARK13, Which Confers Thermotolerance, Targets Misfolded Proteins*
Background: Mutations in PARK13 have been implicated in Parkinson disease. Results: AtPARK13 confers thermotolerance in Arabidopsis and degrades misfolded proteins, including α-synuclein and DJ-1.Expand
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A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells
MicroRNAs are key regulators associated with numerous diseases. In HEK293 cells, miR-153-3p and miR-205-5p down-regulate alpha-synuclein (SNCA) and Leucine-rich repeat kinase 2 (LRRK2), two keyExpand
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miR‐15a‐5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway
Essentials The action of microRNAs (miRs) in human megakaryocyte signaling is largely unknown. Cord blood‐derived human megakaryocytes (MKs) were used to test the function of candidate miRs.Expand
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Subcellular Parkinson’s Disease-Specific Alpha-Synuclein Species Show Altered Behavior in Neurodegeneration
Parkinson’s disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered anExpand
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