Indranee Y Amarasinghe

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BACKGROUND Breast Cancer is the most commonly diagnosed cancer among Sri Lankan women. Germline mutations in the susceptibility genes BRCA1 and BRCA2 in hereditary breast/ovarian cancer, though low in prevalence, are highly penetrant and show geographical variations. There have been only a few reports from Asia on mutations in BRCA1/2 genes and none from(More)
Majority of mutations found to date in the BRCA1/BRCA2 genes in breast and/or ovarian cancer families are point mutations or small insertions and deletions scattered over the coding sequence and splice junctions. Such mutations and sequence variants of BRCA1 and BRCA2 genes were previously identified in a group of Sri Lankan breast cancer patients. Large(More)
BACKGROUND There are not many publications on the prognostic implications of nodal disease in patients with papillary thyroid cancers (PTC). This study explored the distribution of nodes with respect to the levels, optimal management of the neck for patients with PTC, and its survival advantages. METHODS Followup of 79 patients with thyroid cancer (59(More)
This paper describes a project funded by DFID (Department of International Development of the United Kingdom) for the establishment of breast clinic in an oncological center in a developing country, Sri Lanka. In Sri Lanka the commonest female cancer is breast cancer, with an incidence of 7.7 per 100,000. The project utilized a link with an existing breast(More)
Leptin and visfatin are implicated in breast cancer risk but studies accounting for bioavailability of leptin are sparse. Reports on the association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with breast cancer are also inconsistent. Only a very few studies have examined biochemical and genetic variables concomitantly in the same(More)
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